USP7 and TRAF4

Number of citations of the paper that reports this interaction (PMID 11279055)
30

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		USP7	TRAF4
Gene Name		ubiquitin specific peptidase 7 (herpes virus-associated)	TNF receptor-associated factor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol PML Body	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Tight Junction Perinuclear Region Of Cytoplasm
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding	DNA Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding WW Domain Binding
	Biological Process	Transcription-coupled Nucleotide-excision Repair Multicellular Organismal Development Maintenance Of DNA Methylation Viral Process Histone Deubiquitination Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Protein Ubiquitination Respiratory Tube Development Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Protein Homodimerization Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		85 interactors: ACD ARNT2 ATXN1 BCOR BEND5 BMI1 CBX8 CHEK1 CLSPN CREB3L3 DAXX DNAJA3 DNMT1 DNMT3A EWSR1 EZH2 FAM175B FOXN2 HECW1 HERPUD1 HIST3H2BB HTRA2 KAT5 KLHL8 MAGEE1 MAL MARCH7 MCMBP MDM2 MDM4 MYD88 NECAB2 PCGF2 PEG3 PEPD PHLDB2 PICK1 PJA1 PLA2G2A PLEKHO1 PPARG PPL RADIL RARA RB1 RBCK1 RELA RFFL RING1 RNF2 RNF220 SMAD3 SUMO1 SUZ12 SYVN1 TANK TBCB TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM27 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBC UBE2E1 UBE2S UHRF2 USP15 USP21 USP28 WWP2 XPC ZEB1 ZMYND8 ZNF423	69 interactors: ALKBH4 ARNT2 BAHD1 BANP BCKDK BCL6B BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FBXL18 FTH1 GORASP2 GPRASP1 HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGED1 MAP3K4 MRPL28 NCF1 NGFR NGFRAP1 NOS1AP NPAS2 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581
Entrez ID		7874	9618
HPRD ID		03950	03915
Ensembl ID		ENSG00000187555	ENSG00000076604
Uniprot IDs		B7Z815 Q6U8A4 Q93009	Q9BUZ4
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ	2EOD 2YUC 4M4E
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Metabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Process Modification-dependent Protein Catabolic Process Chromosome Organization Chromatin Organization Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Transcription, DNA-templated Cellular Macromolecule Catabolic Process Apoptotic Process RNA Biosynthetic Process Programmed Cell Death Chromatin Modification Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Histone Ubiquitination Cell Death	Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Signaling Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Response To Cytokine Cellular Protein Catabolic Process Cell Death Death Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process
Tagcloud ?		accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna	bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Difference) ?		accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna	bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Intersection) ?