SUMO1 and KDM1A

Number of citations of the paper that reports this interaction (PMID 15561718)
45

Data Source:
BioGRID (enzymatic study)

		SUMO1	KDM1A
Gene Name		small ubiquitin-like modifier 1	lysine (K)-specific demethylase 1A
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Gene Ontology Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm PML Body Nuclear Speck Dendrite Nuclear Membrane Synapse	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding Transcription Factor Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	RNA Polymerase II Transcription Factor Binding P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Oxidoreductase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-K9 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) MRF Binding Transcription Regulatory Region DNA Binding Flavin Adenine Dinucleotide Binding Androgen Receptor Binding
	Biological Process	DNA Repair Protein Sumoylation Cytokine-mediated Signaling Pathway PML Body Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Palate Development Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Localization To Nuclear Pore	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Demethylation Blood Coagulation Cell Proliferation Regulation Of Primitive Erythrocyte Differentiation Pituitary Gland Development Granulocyte Differentiation Negative Regulation Of Protein Binding Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Muscle Cell Development Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Interferon gamma signaling SUMO is proteolytically processed Post-translational protein modification SUMOylation Interferon Signaling Cytokine Signaling in Immune system SUMO is conjugated to E1 (UBA2:SAE1) Regulation of IFNG signaling SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HDMs demethylate histones Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		194 interactors: ADD3 APP AR ARL13A ATF2 ATF3 ATXN1 ATXN3 ATXN7 AURKA AURKB BCAM BCL11A BIRC3 BLM BRCA1 C11orf65 C18orf25 CAMSAP2 CARD9 CASP2 CASP8 CCDC67 CD40 CDCA8 CHAF1A CHD3 CHD4 COG1 CTNNA1 DAXX DDX24 DNM1 DNMT3A DNMT3B DTX2 EDARADD ESR1 ETV1 ETV4 ETV6 FADD FAM118B FANCM FAS FASLG FBF1 FLI1 FOS FOXL2 FOXM1 GATA1 GLP1R GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HIRA HNF4A HNRNPC HNRNPK HSF1 HSF2 HTT ING2 IRAK1 JUN KAT2A KAT6B KDM1A KRT14 KRT18 KRT5 KRT8 MAP2K1 MAPK1IP1L MDC1 MDM2 MECOM MEF2A MEF2C MITF MKL1 MSX1 MUL1 MX1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NELFE NFE2L2 NFKBIA NIN NOS1 NOX5 NR3C1 NR3C2 PARK7 PARP1 PAX6 PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIK3C3 PLK3 PML PPARA PPM1J RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBM25 RHOXF2 RNF4 RPS3 SAE1 SALL1 SART1 SATB1 SEMA6A SENP1 SENP2 SENP6 SETX SH3KBP1 SLC2A1 SOX10 SOX2 SOX6 SP1 SP100 SP3 SREBF1 SREBF2 SSRP1 STAB2 STK24 STMN2 SUMO1P1 SUMO2 SUPT7L SYMPK TCERG1 TCF4 TDG TDP2 TFCP2 TGM2 TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF4 TRIM24 TRIM5 TRPS1 TSC22D3 TSHZ2 TSNAX UBA2 UBE2I USP25 USP7 USPL1 WNK1 WRN XRCC1 XRCC5 ZBTB16 ZBTB26 ZBTB6 ZBTB7A ZCCHC12 ZCCHC7 ZMYM2 ZMYM5 ZNF24 ZNF451	219 interactors: AKAP9 ANKEF1 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5J2 ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BLZF1 BMP3 BRCA1 C16orf59 C17orf82 C18orf54 C4orf17 C8orf48 C8orf74 CCDC121 CCDC14 CCDC151 CCDC155 CCDC172 CCDC37 CCDC53 CCDC74A CCDC74B CCDC90B CDC23 CDC5L CDCA4 CDCA5 CENPQ CEP162 CEP70 CRBN CRLF3 CTBP1 DBF4B DNAJA3 DNTTIP1 DYX1C1 E2F1 ECI2 ELOF1 EXOC1 EZH2 FAM9A FIGNL1 FYCO1 FYN GABPB2 GDF9 GLYR1 GOLGA2 GPATCH2L GSTCD GTPBP2 H3F3C HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HIST1H3A HIST2H3C HIST3H3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INTS2 ISL1 ITGB3BP ITSN2 KANSL1 KDM5B KIAA0408 KIFC3 KLC3 KLF3 KLHDC4 KRT17 KRT19 KRT222 KRT33B KRT38 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LOXL4 MALT1 MBD3 MBD4 MCPH1 MCRS1 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NDUFA8 NDUFS1 NECAB2 NEFL NF2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 OFCC1 OIP5 OPA3 OTUB1 PDCD5 PDE4DIP PEX7 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 RASSF1 RASSF2 RASSF8 RCOR1 RCOR3 RNF10 RPRD1A SAMD3 SEPT6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO1 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TERF1 TEX35 TEX9 TNFAIP1 TNNT2 TP53 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC33 UBA3 UCHL5 UNC119 UNKL USP28 VPS11 VPS37A WBSCR27 WDR83 YEATS4 ZBTB24 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF829
Entrez ID		7341	23028
HPRD ID		03554	09800
Ensembl ID		ENSG00000116030	ENSG00000004487
Uniprot IDs		P63165	O60341
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP	2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Apoptotic Process Biosynthetic Process Cellular Metabolic Process Regulation Of Cellular Process Organelle Organization Chromosome Organization Cellular Response To Organic Substance Protein Sumoylation Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Developmental Process Programmed Cell Death Apoptotic Process Peptidyl-lysine Modification	Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Organelle Organization Gene Expression RNA Metabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Chromosome Organization Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Cellular Component Organization Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation	aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation	aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting
Tagcloud (Intersection) ?