KDM1A and NEFL

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		KDM1A	NEFL
Gene Name		lysine (K)-specific demethylase 1A	neurofilament, light polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Cytoplasm Cytosol Neurofilament Axon Growth Cone TSC1-TSC2 Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Oxidoreductase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-K9 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) MRF Binding Transcription Regulatory Region DNA Binding Flavin Adenine Dinucleotide Binding Androgen Receptor Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Demethylation Blood Coagulation Cell Proliferation Regulation Of Primitive Erythrocyte Differentiation Pituitary Gland Development Granulocyte Differentiation Negative Regulation Of Protein Binding Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Muscle Cell Development Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Microtubule Cytoskeleton Organization Synaptic Transmission Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axon Transport Of Mitochondrion Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone
Pathways		Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HDMs demethylate histones Factors involved in megakaryocyte development and platelet production	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		219 interactors: AKAP9 ANKEF1 AP1G2 AR ARHGAP15 ARHGAP29 ASB10 ASB3 ASCC2 ATP5J2 ATP6V1B1 BAHD1 BAIAP2 BATF BCAT1 BLZF1 BMP3 BRCA1 C16orf59 C17orf82 C18orf54 C4orf17 C8orf48 C8orf74 CCDC121 CCDC14 CCDC151 CCDC155 CCDC172 CCDC37 CCDC53 CCDC74A CCDC74B CCDC90B CDC23 CDC5L CDCA4 CDCA5 CENPQ CEP162 CEP70 CRBN CRLF3 CTBP1 DBF4B DNAJA3 DNTTIP1 DYX1C1 E2F1 ECI2 ELOF1 EXOC1 EZH2 FAM9A FIGNL1 FYCO1 FYN GABPB2 GDF9 GLYR1 GOLGA2 GPATCH2L GSTCD GTPBP2 H3F3C HAUS1 HAUS3 HAUS6 HDAC1 HESX1 HIST1H3A HIST2H3C HIST3H3 HOXA1 ID2 IFI35 IGFBP4 IK IKBIP IL16 IMMT INTS2 ISL1 ITGB3BP ITSN2 KANSL1 KDM5B KIAA0408 KIFC3 KLC3 KLF3 KLHDC4 KRT17 KRT19 KRT222 KRT33B KRT38 KRT6A KRT6B KRT7 L3MBTL3 LENG8 LOXL4 MALT1 MBD3 MBD4 MCPH1 MCRS1 MLC1 MNS1 MTA3 MTF2 MTMR9 MTO1 MYC MYLIP NBPF15 NDUFA8 NDUFS1 NECAB2 NEFL NF2 NMI NOSTRIN NR1H2 NR1H3 NR2C2 NR2E1 OFCC1 OIP5 OPA3 OTUB1 PDCD5 PDE4DIP PEX7 PHC2 PHF19 PHF20L1 PHF21A PMF1 PNKP PPARD PPP1R12A PRDM1 PRIM2 PSMC1 PSMC3 RASSF1 RASSF2 RASSF8 RCOR1 RCOR3 RNF10 RPRD1A SAMD3 SEPT6 SERGEF SETDB1 SF3B2 SH3GLB2 SLU7 SMAD9 SMARCD1 SMN1 SNF8 SNX15 SOCS6 SPATA22 SPATA24 SPICE1 SPRY2 SPSB1 SPZ1 SRGAP3 SSX2IP STAT3 STX11 STX19 SUMO1 SUMO2 SUV39H1 TACC1 TADA3 TAL1 TDO2 TERF1 TEX35 TEX9 TNFAIP1 TNNT2 TP53 TRAF4 TRIM39 TRIM54 TSACC TSC1 TTC33 UBA3 UCHL5 UNC119 UNKL USP28 VPS11 VPS37A WBSCR27 WDR83 YEATS4 ZBTB24 ZCCHC17 ZFP28 ZNF280A ZNF333 ZNF436 ZNF451 ZNF480 ZNF581 ZNF641 ZNF71 ZNF829	29 interactors: BRD7 CCNC CDK5RAP2 CHD3 ENKD1 GRIN1 KDM1A KIFC3 KRT15 MAP2 MTMR2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SPTAN1 TERF1 TEX11 TSC1 TXLNB USP2 VIM YWHAG
Entrez ID		23028	4747
HPRD ID		09800	01206
Ensembl ID		ENSG00000004487
Uniprot IDs		O60341	P07196
PDB IDs		2COM 2DW4 2EJR 2H94 2HKO 2IW5 2L3D 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 2Z3Y 2Z5U 3ABT 3ABU 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Organelle Organization Gene Expression RNA Metabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Chromosome Organization Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Cellular Component Organization Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation	Nervous System Development Developmental Process Anatomical Structure Development Regulation Of Cellular Component Organization System Development Central Nervous System Development Organelle Organization Cell Differentiation Cell Projection Organization Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Neurogenesis Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Cell Cycle Cell Development Movement Of Cell Or Subcellular Component Microtubule-based Process Intermediate Filament Organization Axonogenesis Regulation Of Cellular Process Response To Stimulus G2/M Transition Of Mitotic Cell Cycle Axon Development Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Cellular Component Maintenance Chromatin Modification Negative Regulation Of Biosynthetic Process Neuron Development Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Myelination Axon Ensheathment Chromosome Organization Cell Cycle Process Regulation Of Gene Expression Regulation Of Microtubule-based Process Chromatin Organization Cell Morphogenesis Involved In Differentiation Intermediate Filament Cytoskeleton Organization Neuron Differentiation Intermediate Filament-based Process Protein Oligomerization Microtubule Bundle Formation Microtubule Cytoskeleton Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Tagcloud ?		aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment exhibiting h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		aml blasts ccaat confers corepressor corest demethylase demethylates depleted di engrafted engraftment h3k4me3 hdi lsd1 mark me2 mono npm1 oncoproteins pan panobinostat permissive ps shrna sp2509 synergistically warranting	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?		exhibiting