TMSB4X and ACTG1

Number of citations of the paper that reports this interaction (PMID 15163409)
61

Data Source:
HPRD (in vitro, in vivo)

		TMSB4X	ACTG1
Gene Name		thymosin beta 4, X-linked	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoskeleton Platelet Alpha Granule Lumen	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Monomer Binding Protein Binding Poly(A) RNA Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Blood Coagulation Platelet Activation Sequestering Of Actin Monomers	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ACTA1 ACTA2 ACTB ACTG1 ALAS1 ANXA7 APLP1 CDKN1A FAM118B GRB7 IGSF21 ILK KRT13 KRT15 KRT31 KRT40 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		7114	71
HPRD ID		02153	00017
Ensembl ID		ENSG00000205542	ENSG00000184009
Uniprot IDs		A2VCK8 P62328 Q0P5T0	P63261
PDB IDs		1UY5 3TU5
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Cell Junction Assembly Platelet Aggregation Anatomical Structure Development Response To Stimulus Cell Aging Cell-cell Junction Organization Hemostasis Protein Oligomerization Epithelium Development Adherens Junction Organization Developmental Process Tissue Development Regulation Of Body Fluid Levels Cell-matrix Adhesion Regulation Of Protein Import Into Nucleus Blood Coagulation Cellular Response To Stimulus Platelet Activation Fetal Process Involved In Parturition Regulation Of Protein Localization To Nucleus Cell Adhesion Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Nucleocytoplasmic Transport Cell-substrate Adhesion Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Multicellular Organismal Development Retina Homeostasis Response To Organic Cyclic Compound Single Organismal Cell-cell Adhesion Negative Regulation Of Interleukin-2 Secretion Skeletal Muscle Cell Proliferation Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Skeletal Muscle Fiber Adaptation Negative Regulation Of Gene Expression System Development Regulation Of Intracellular Protein Transport Phagocytosis Organ Development Fc Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Myofibril Assembly Cellular Response To Norepinephrine Stimulus Wound Healing Negative Regulation Of Transferase Activity Regulation Of Protein Transport Protein Complex Assembly	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		aldo3 bhlhb2 bnip3 bnip31 cdknla cnn2 cobalt eno2 exerting f10 fdr hk2 itga4 lgals3 mcam mimicry mxil nominal nppb pfkp pkp2 probesets sap30 selenbpl singular u74av2 unsupervised vegfa wise	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		aldo3 bhlhb2 bnip3 bnip31 cdknla cnn2 cobalt eno2 exerting f10 fdr hk2 itga4 lgals3 mcam mimicry mxil nominal nppb pfkp pkp2 probesets sap30 selenbpl singular u74av2 unsupervised vegfa wise	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?