TMSB4X and ALAS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TMSB4X	ALAS1
Gene Name		thymosin beta 4, X-linked	5-aminolevulinate synthase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoskeleton Platelet Alpha Granule Lumen	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Actin Monomer Binding Protein Binding Poly(A) RNA Binding	5-aminolevulinate Synthase Activity Pyridoxal Phosphate Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Blood Coagulation Platelet Activation Sequestering Of Actin Monomers	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Organelle Organization Mitochondrion Organization Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	PPARA activates gene expression Heme biosynthesis Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Metabolism of porphyrins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Glycine
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		29 interactors: ACTA1 ACTA2 ACTB ACTG1 ALAS1 ANXA7 APLP1 CDKN1A FAM118B GRB7 IGSF21 ILK KRT13 KRT15 KRT31 KRT40 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6	40 interactors: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK DUSP19 EP400 FAM127C GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		7114	211
HPRD ID		02153	00505
Ensembl ID		ENSG00000205542	ENSG00000023330
Uniprot IDs		A2VCK8 P62328 Q0P5T0	P13196 Q5JAM2
PDB IDs		1UY5 3TU5
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Cell Junction Assembly Platelet Aggregation Anatomical Structure Development Response To Stimulus Cell Aging Cell-cell Junction Organization Hemostasis Protein Oligomerization Epithelium Development Adherens Junction Organization Developmental Process Tissue Development Regulation Of Body Fluid Levels Cell-matrix Adhesion Regulation Of Protein Import Into Nucleus Blood Coagulation Cellular Response To Stimulus Platelet Activation Fetal Process Involved In Parturition Regulation Of Protein Localization To Nucleus Cell Adhesion Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Nucleocytoplasmic Transport Cell-substrate Adhesion Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Multicellular Organismal Development Retina Homeostasis Response To Organic Cyclic Compound Single Organismal Cell-cell Adhesion Negative Regulation Of Interleukin-2 Secretion Skeletal Muscle Cell Proliferation Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Skeletal Muscle Fiber Adaptation Negative Regulation Of Gene Expression System Development Regulation Of Intracellular Protein Transport Phagocytosis Organ Development Fc Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Myofibril Assembly Cellular Response To Norepinephrine Stimulus Wound Healing Negative Regulation Of Transferase Activity Regulation Of Protein Transport Protein Complex Assembly	Sequestering Of Actin Monomers Blood Coagulation Hemostasis Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity
Tagcloud ?		aldo3 bhlhb2 bnip3 bnip31 cdknla cnn2 cobalt eno2 exerting f10 fdr hk2 itga4 lgals3 mcam mimicry mxil nominal nppb pfkp pkp2 probesets sap30 selenbpl singular u74av2 unsupervised vegfa wise	adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Difference) ?		aldo3 bhlhb2 bnip3 bnip31 cdknla cnn2 cobalt eno2 exerting f10 fdr hk2 itga4 lgals3 mcam mimicry mxil nominal nppb pfkp pkp2 probesets sap30 selenbpl singular u74av2 unsupervised vegfa wise	adequate arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative pum1 regardless secretory softwares standards taqman trim27 ube2d2
Tagcloud (Intersection) ?