TLE1 and TCF3

Number of citations of the paper that reports this interaction (PMID 24596249)
1

Data Source:
BioGRID (pull down)

		TLE1	TCF3
Gene Name		transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	transcription factor 3
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Protein Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Protein Binding Transcription Factor Binding Identical Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Enhancer Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Multicellular Organismal Development Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Anoikis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation B Cell Lineage Commitment Transcription, DNA-templated Regulation Of Transcription, DNA-templated B Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Response To Drug Muscle Cell Differentiation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Peyer's Patch Development Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		85 interactors: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY VENTX ZFP64	62 interactors: AEBP1 ASCL3 BHLHA15 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DAXX ELK3 EP300 FERD3L HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MAX MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NHLH1 PDX1 PRKACA PSMD4 PSMD9 RALGAPA1 RPL37 RUFY1 RUNX1T1 SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1 VDR
Entrez ID		7088	6929
HPRD ID		02557	00918
Ensembl ID		ENSG00000196781	ENSG00000071564
Uniprot IDs		Q04724	P15923 Q2TB39
PDB IDs		1GXR 2CE8 2CE9	1HLH 2YPA 2YPB 3U5V
Enriched GO Terms of Interacting Partners?		System Development Nervous System Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Regulation Of Gene Expression Epithelium Development Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Tissue Development Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Organ Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Neurogenesis RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Generation Of Neurons Anatomical Structure Morphogenesis Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Central Nervous System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organ Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Anatomical Structure Development Multicellular Organismal Development Developmental Process Embryo Development Tissue Development Organ Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Embryonic Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Embryonic Organ Development
Tagcloud ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Difference) ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Intersection) ?