TLE1 and SIX2

Number of citations of the paper that reports this interaction (PMID 12441302)
36

Data Source:
HPRD (two hybrid)

		TLE1	SIX2
Gene Name		transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	SIX homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Membrane
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Protein Binding Transcription Factor Binding Identical Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Multicellular Organismal Development Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Anoikis	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS		Hippocampal atrophy ( 22745009) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Metabolite levels ( 21909109)
Protein-Protein Interactions		85 interactors: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY VENTX ZFP64	5 interactors: AES APP EYA1 EYA3 TLE1
Entrez ID		7088	10736
HPRD ID		02557	05408
Ensembl ID		ENSG00000196781	ENSG00000170577
Uniprot IDs		Q04724	Q8TBA2 Q9NPC8
PDB IDs		1GXR 2CE8 2CE9
Enriched GO Terms of Interacting Partners?		System Development Nervous System Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Regulation Of Gene Expression Epithelium Development Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Tissue Development Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Organ Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Neurogenesis RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Generation Of Neurons Anatomical Structure Morphogenesis Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Central Nervous System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Histone Dephosphorylation Regulation Of Anoikis Anatomical Structure Morphogenesis Positive Regulation Of DNA Repair RNA Metabolic Process Response To Radiation Gene Expression Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Multicellular Organismal Development Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Protein Binding Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of Gene Expression Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Wnt Signaling Pathway Developmental Process Organ Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Anoikis Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Protein Dephosphorylation Neurological System Process Negative Regulation Of Signaling Organ Development Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Tagcloud ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures eya1 gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 superficially susceptibile thinning wnt4
Tagcloud (Difference) ?		activates carcinogenesis colony contributed contributes deregulation dramatically dysregulation enhancer growing hcc hepatic hepatitis hepatocarcinogenesis hepatocellular immunodeficient indicates insights kappa largely micrornas mir mirna mirnas transducin tumorigenesis untranslated utr whereby	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures eya1 gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 superficially susceptibile thinning wnt4
Tagcloud (Intersection) ?