TERF1 and MAPK12

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF1	MAPK12
Gene Name		telomeric repeat binding factor (NIMA-interacting) 1	mitogen-activated protein kinase 12
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of DNA Replication Positive Regulation Of Microtubule Polymerization Telomeric Loop Formation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Protein Homooligomerization Cell Division Negative Regulation Of Telomerase Activity	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Muscle Cell Differentiation Myoblast Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Signalling to ERKs Signalling by NGF Organelle biogenesis and maintenance CDO in myogenesis NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Mitochondrial biogenesis DSCAM interactions Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF NOD1/2 Signaling Pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways p38MAPK events Signalling to RAS Innate Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		200 interactors: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 APEX1 ARHGDIA ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C19orf66 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS HCLS1 HDGFRP2 HEXIM1 HEXIM2 HGD HIST1H1A HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KDM1A KEAP1 KIAA1279 KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MSN MT1X MVK NAP1L1 NBN NEFL NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS SBDS SET SH3BP1 SH3GL2 SH3GL3 SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UTP14A WARS WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	25 interactors: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBB2IP GRB2 GTF2I HTRA2 INADL MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PKN1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		7013	6300
HPRD ID		02975	03868
Ensembl ID		ENSG00000147601	ENSG00000188130
Uniprot IDs		P54274	B7Z274 P53778
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82	1CM8
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Organelle Organization Heterocycle Metabolic Process Telomere Maintenance Catabolic Process Small Molecule Metabolic Process Cellular Process Pathogenesis Carbohydrate Biosynthetic Process Monosaccharide Metabolic Process Regulation Of Cellular Component Organization Glucose Metabolic Process Carboxylic Acid Metabolic Process Chromosome Organization Biosynthetic Process Organic Acid Metabolic Process Carbohydrate Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Ribose Phosphate Metabolic Process Pyruvate Metabolic Process Telomere Maintenance Via Telomere Lengthening Cellular Component Assembly Protein Complex Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gluconeogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Hexose Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Organophosphate Metabolic Process Hexose Biosynthetic Process Cell Cycle Process Mitotic Cell Cycle Metabolic Process Nucleotide Metabolic Process Regulation Of Organelle Organization Nicotinamide Nucleotide Metabolic Process Pentose Biosynthetic Process Glucose 6-phosphate Metabolic Process Response To Organic Substance Regulation Of Telomere Maintenance Regulation Of DNA Replication NADP Metabolic Process Aromatic Compound Catabolic Process	Receptor Localization To Synapse Regulation Of Phosphorus Metabolic Process Protein Localization To Synapse Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Cell Communication Regulation Of Metabolic Process Regulation Of MAPK Cascade Muscle System Process Receptor Clustering Activation Of Protein Kinase Activity Activation Of MAPK Activity Nucleotide Phosphorylation Response To Stimulus Regulation Of Cellular Process Phosphorylation Intracellular Signal Transduction Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of MAP Kinase Activity Muscle Contraction Cellular Response To Sorbitol MAPK Cascade Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Axonogenesis Positive Regulation Of Transferase Activity Regulation Of Signaling Axon Development Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Intersection) ?