TERF1 and EPHX2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF1	EPHX2
Gene Name		telomeric repeat binding factor (NIMA-interacting) 1	epoxide hydrolase 2, cytoplasmic
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle	Cytoplasm Peroxisome Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Magnesium Ion Binding Epoxide Hydrolase Activity Receptor Binding Toxic Substance Binding Phosphatase Activity 10-hydroxy-9-(phosphonooxy)octadecanoate Phosphatase Activity Lipid Phosphatase Activity Protein Homodimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of DNA Replication Positive Regulation Of Microtubule Polymerization Telomeric Loop Formation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Protein Homooligomerization Cell Division Negative Regulation Of Telomerase Activity	Xenobiotic Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Regulation Of Blood Pressure Response To Toxic Substance Positive Regulation Of Gene Expression Dephosphorylation Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Cholesterol Homeostasis Small Molecule Metabolic Process Positive Regulation Of Vasodilation Stilbene Catabolic Process Phospholipid Dephosphorylation Reactive Oxygen Species Metabolic Process Regulation Of Cholesterol Metabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Drugs			N-Cyclohexyl-N\'-(4-Iodophenyl)Urea N-Cyclohexyl-N\'-Decylurea N-Cyclohexyl-N\'-(Propyl)Phenyl Urea N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID
Diseases
GWAS		Crohn's disease ( 22412388)	Dental caries ( 23259602)
Protein-Protein Interactions		200 interactors: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 APEX1 ARHGDIA ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C19orf66 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS HCLS1 HDGFRP2 HEXIM1 HEXIM2 HGD HIST1H1A HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KDM1A KEAP1 KIAA1279 KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MSN MT1X MVK NAP1L1 NBN NEFL NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS SBDS SET SH3BP1 SH3GL2 SH3GL3 SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UTP14A WARS WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	4 interactors: MVP NIPSNAP3A PEX5 TERF1
Entrez ID		7013	2053
HPRD ID		02975	00582
Ensembl ID		ENSG00000147601	ENSG00000120915
Uniprot IDs		P54274	P34913
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82	1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 4HAI 4J03 4JNC
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Organelle Organization Heterocycle Metabolic Process Telomere Maintenance Catabolic Process Small Molecule Metabolic Process Cellular Process Pathogenesis Carbohydrate Biosynthetic Process Monosaccharide Metabolic Process Regulation Of Cellular Component Organization Glucose Metabolic Process Carboxylic Acid Metabolic Process Chromosome Organization Biosynthetic Process Organic Acid Metabolic Process Carbohydrate Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Ribose Phosphate Metabolic Process Pyruvate Metabolic Process Telomere Maintenance Via Telomere Lengthening Cellular Component Assembly Protein Complex Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gluconeogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Hexose Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Organophosphate Metabolic Process Hexose Biosynthetic Process Cell Cycle Process Mitotic Cell Cycle Metabolic Process Nucleotide Metabolic Process Regulation Of Organelle Organization Nicotinamide Nucleotide Metabolic Process Pentose Biosynthetic Process Glucose 6-phosphate Metabolic Process Response To Organic Substance Regulation Of Telomere Maintenance Regulation Of DNA Replication NADP Metabolic Process Aromatic Compound Catabolic Process	Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Negative Regulation Of Protein Homooligomerization Negative Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Protein Oligomerization Peroxisomal Membrane Transport Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Microtubule Polymerization Protein Import Into Peroxisome Matrix Regulation Of Telomerase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Negative Regulation Of Catalytic Activity Very Long-chain Fatty Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Regulation Of Microtubule Polymerization Regulation Of Protein Autophosphorylation Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Endoplasmic Reticulum Organization Negative Regulation Of Chromosome Segregation Fatty Acid Beta-oxidation Peroxisome Organization Protein Complex Assembly
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal	25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid
Tagcloud (Intersection) ?