STAT2 and STAT1

Number of citations of the paper that reports this interaction (PMID 8621447)
39

Data Source:
HPRD (in vivo)

		STAT2	STAT1
Gene Name		signal transducer and activator of transcription 2, 113kDa	signal transducer and activator of transcription 1, 91kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Identical Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter JAK-STAT Cascade Viral Process Cytokine-mediated Signaling Pathway Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Negative Regulation Of Macrophage Fusion Cellular Response To Interferon-beta Response To Drug Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Renal Tubule Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Signaling by PDGF Signaling by FGFR in disease ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Signaling by SCF-KIT Downstream signal transduction Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Height ( 20881960 23456168) Psoriasis ( 19169254)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: CREBBP CXCR4 EP300 FNTA GAA HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2	103 interactors: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DOT1L DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 ERBB2 FADD FANCC FGFR3 FGFR4 FLT1 FOS FYN GFAP GNB2L1 GTF2I HADH HLA-B HSF1 HSP90AB1 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBC UBE2I VDR XPO1 ZNF467
Entrez ID		6773	6772
HPRD ID		02778	02777
Ensembl ID		ENSG00000170581	ENSG00000115415
Uniprot IDs		P52630 R9QE65	J3KPM9 P42224
PDB IDs		2KA4	1BF5 1YVL 2KA6
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response Cellular Response To Organic Substance Response To Cytokine Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Response To Organic Substance Regulation Of Innate Immune Response Regulation Of Signal Transduction JAK-STAT Cascade Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Response To Stress Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Signaling Cell Communication Response To Virus Regulation Of Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Interferon-gamma-mediated Signaling Pathway Interaction With Symbiont Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Autophosphorylation Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cytokine Production Positive Regulation Of Gene Expression Regulation Of Tubulin Deacetylation Cellular Response To Stimulus Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Response To Interferon-gamma Histone Modification Response To Other Organism Transcription, DNA-templated Response To Biotic Stimulus	Cellular Response To Organic Substance Response To Organic Substance Defense Response Innate Immune Response Response To Cytokine Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Signaling Response To Stress Regulation Of Immune System Process Cell Communication Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Protein Autophosphorylation Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Regulation Of Signaling Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Viral Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stat5 stat5b stats yeast