STAT2 and GAA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		STAT2	GAA
Gene Name		signal transducer and activator of transcription 2, 113kDa	glucosidase, alpha; acid
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Lysosome Lysosomal Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Identical Protein Binding	Alpha-1,4-glucosidase Activity Carbohydrate Binding Maltose Alpha-glucosidase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter JAK-STAT Cascade Viral Process Cytokine-mediated Signaling Pathway Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Glycogen Catabolic Process Sucrose Metabolic Process Glucose Metabolic Process Lysosome Organization Locomotory Behavior Tissue Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs			Acarbose Miglitol
Diseases
GWAS		Height ( 20881960 23456168) Psoriasis ( 19169254)
Protein-Protein Interactions		17 interactors: CREBBP CXCR4 EP300 FNTA GAA HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2	5 interactors: EP300 HIVEP1 NCF1 NUMBL STAT2
Entrez ID		6773	2548
HPRD ID		02778	06006
Ensembl ID		ENSG00000170581	ENSG00000171298
Uniprot IDs		P52630 R9QE65	P10253
PDB IDs		2KA4
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response Cellular Response To Organic Substance Response To Cytokine Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Response To Organic Substance Regulation Of Innate Immune Response Regulation Of Signal Transduction JAK-STAT Cascade Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Response To Stress Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Signaling Cell Communication Response To Virus Regulation Of Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Interferon-gamma-mediated Signaling Pathway Interaction With Symbiont Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Autophosphorylation Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cytokine Production Positive Regulation Of Gene Expression Regulation Of Tubulin Deacetylation Cellular Response To Stimulus Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Response To Interferon-gamma Histone Modification Response To Other Organism Transcription, DNA-templated Response To Biotic Stimulus	Interaction With Symbiont Histone H2B Acetylation Innate Immune Response Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Respiratory Burst Involved In Defense Response Response To Yeast Cell Surface Receptor Signaling Pathway Immune Response Killing By Host Of Symbiont Cells Defense Response Hydrogen Peroxide Biosynthetic Process Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation Respiratory Burst Forebrain Neuroblast Division Negative Regulation Of Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Superoxide Anion Generation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Neutrophil Mediated Immunity Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Lateral Ventricle Development Viral Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Killing Of Cells Of Other Organism Somatic Stem Cell Division Cellular Response To Cytokine Stimulus N-terminal Protein Amino Acid Modification Defense Response To Fungus Regulation Of Cellular Response To Heat Immune System Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Mediated Cytotoxicity Hydrogen Peroxide Metabolic Process Leukotriene Metabolic Process Biosynthetic Process Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Transcription, DNA-templated Response To Cytokine Response To Fungus Response To Other Organism Regulation Of Type I Interferon-mediated Signaling Pathway
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast	birds corrected correction deficient endocytic endocytosed endocytosis existed fibroblasts glucosidase glycogen hamster illustrate kd lasted lethal lysosomes maltase mammals man myoblasts nmol normalize normalized ovary pompe quail replacement subfractions
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast	birds corrected correction deficient endocytic endocytosed endocytosis existed fibroblasts glucosidase glycogen hamster illustrate kd lasted lethal lysosomes maltase mammals man myoblasts nmol normalize normalized ovary pompe quail replacement subfractions
Tagcloud (Intersection) ?