STAT1 and MAVS

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		STAT1	MAVS
Gene Name		signal transducer and activator of transcription 1, 91kDa	mitochondrial antiviral signaling protein
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity	Signal Transducer Activity Protein Binding Protein Kinase Binding CARD Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Negative Regulation Of Macrophage Fusion Cellular Response To Interferon-beta Response To Drug Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Renal Tubule Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Signal Transduction Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus, Translocation RIG-I Signaling Pathway Defense Response To Bacterium Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization
Pathways		Signaling by PDGF Signaling by FGFR in disease ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Signaling by SCF-KIT Downstream signal transduction Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		103 interactors: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DOT1L DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 ERBB2 FADD FANCC FGFR3 FGFR4 FLT1 FOS FYN GFAP GNB2L1 GTF2I HADH HLA-B HSF1 HSP90AB1 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBC UBE2I VDR XPO1 ZNF467	19 interactors: ABL1 BAG6 CALCOCO2 DDX58 IRF3 IRF5 IRF7 KCNIP3 MAP3K7 OAS3 RIPK2 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF5 TRAF6 UBE4A
Entrez ID		6772	57506
HPRD ID		02777	13847
Ensembl ID		ENSG00000115415
Uniprot IDs		J3KPM9 P42224	M1P2Z0 Q7Z434
PDB IDs		1BF5 1YVL 2KA6	2VGQ
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Defense Response Innate Immune Response Response To Cytokine Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Signaling Response To Stress Regulation Of Immune System Process Cell Communication Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Protein Autophosphorylation Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Regulation Of Signaling Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Viral Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process	Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Response To Other Organism Response To Biotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Activation Of Innate Immune Response Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type I Interferon Production Defense Response Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Response To Virus Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Response To Bacterium Response To Organic Substance Response To Exogenous DsRNA Regulation Of Immune Response Positive Regulation Of Immune Response I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To External Stimulus Programmed Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Organic Substance Response To DsRNA Cell Death Cellular Response To Molecule Of Bacterial Origin Death Response To Interferon-gamma Response To Molecule Of Bacterial Origin Regulation Of Gene Expression Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Intracellular Receptor Signaling Pathway Positive Regulation Of Immune System Process
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast	2b 2c 3c 3cpro adaptors asp classic cleavage comprises conducts cys evasion genera glu innate irf3 irf7 livestock nemo p1 p2 picornavirus polyproteins preference triad trif vp1 vp2 vp3
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast	2b 2c 3c 3cpro adaptors asp classic cleavage comprises conducts cys evasion genera glu innate irf3 irf7 livestock nemo p1 p2 picornavirus polyproteins preference triad trif vp1 vp2 vp3
Tagcloud (Intersection) ?