SPP1 and MAP1B

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	MAP1B
Gene Name		secreted phosphoprotein 1	microtubule-associated protein 1B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Cell Junction Dendritic Spine
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Structural Molecule Activity Protein Binding Microtubule Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Microtubule Bundle Formation Cellular Process Dendrite Development Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Establishment Of Monopolar Cell Polarity
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	27 interactors: ACTB ANP32A ARHGEF11 DYNLL1 EEF1D FOS GABRR1 GABRR2 GAN GSK3B LRRK2 MAG MAGOH MAP1A MAPK8 MARCH5 MINK1 NXF1 NXF2 PAFAH1B1 RASSF1 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2
Entrez ID		6696	4131
HPRD ID		01325	01139
Ensembl ID		ENSG00000118785	ENSG00000131711
Uniprot IDs		B7Z351 P10451 Q3LGB0	P46821 Q6PJD3 Q86X89
PDB IDs		3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Nuclear Export MRNA Export From Nucleus RNA Localization Nucleocytoplasmic Transport Nuclear Transport RNA Export From Nucleus Regulation Of Mitochondrion Organization MRNA Transport RNA Transport Positive Regulation Of Mitochondrion Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytoplasmic Transport Negative Regulation Of Neuron Projection Development Substantia Nigra Development Regulation Of Cell Morphogenesis Termination Of RNA Polymerase II Transcription Signaling Cell Communication Cellular Response To Inorganic Substance Negative Regulation Of Cell Projection Organization Regulation Of Neuron Maturation Response To Metal Ion Regulation Of Axonogenesis Negative Regulation Of Cell Development Neural Nucleus Development Negative Regulation Of Protein Binding Synaptic Transmission Positive Regulation Of Programmed Cell Death Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Death Regulation Of Neuron Projection Development Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Immune System Process Cellular Response To Oxidative Stress DNA-templated Transcription, Termination Neurotrophin TRK Receptor Signaling Pathway Regulation Of Mitochondrial Fission MRNA 3'-end Processing Nervous System Development Neurotrophin Signaling Pathway Regulation Of Intracellular Transport MAPK Cascade
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	accelerated actin assembly barbed bundles cerevisiae coil coiled coisolated coronin coronins crn1delta crn1p cytoskeleton cytoskeletons dimerization filament filaments homologue linking links microtubule microtubules networks nucleation polymerization requirement saccharomyces stabilize
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	accelerated actin assembly barbed bundles cerevisiae coil coiled coisolated coronin coronins crn1delta crn1p cytoskeleton cytoskeletons dimerization filament filaments homologue linking links microtubule microtubules networks nucleation polymerization requirement saccharomyces stabilize
Tagcloud (Intersection) ?