SPP1 and APOA1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPP1	APOA1
Gene Name		secreted phosphoprotein 1	apolipoprotein A-I
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Vesicle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Beta-amyloid Binding Protein Binding Phospholipid Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Retinoid Metabolic Process Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Platelet Degranulation Negative Regulation Of Cytokine Secretion Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Platelet Activation Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Organ Regeneration Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Response To Drug Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress Fiber Assembly Transmembrane Transport Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix	Lipoprotein metabolism PPARA activates gene expression Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Chylomicron-mediated lipid transport Platelet degranulation Amyloids Response to elevated platelet cytosolic Ca2+ Scavenging by Class A Receptors Retinoid metabolism and transport Fatty acid, triacylglycerol, and ketone body metabolism Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Scavenging of heme from plasma Visual phototransduction Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	35 interactors: ABCA1 ABCA13 AKT2 APOA1BP APOA2 APOB APOC1 APOF APOL1 APP ATP5B CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR JAK3 LBP LCAT MAP7D1 MAPK6 PCMT1 PDE1A PLTP PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TTR VKORC1 ZNRD1
Entrez ID		6696	335
HPRD ID		01325	02517
Ensembl ID		ENSG00000118785	ENSG00000118137
Uniprot IDs		B7Z351 P10451 Q3LGB0	P02647
PDB IDs		3CXD 3DSF	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 3J00 3K2S 3R2P
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Cholesterol Metabolic Process Alcohol Metabolic Process Sterol Metabolic Process Cholesterol Transport Sterol Transport Lipid Transport Lipid Localization Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Reverse Cholesterol Transport High-density Lipoprotein Particle Remodeling Small Molecule Metabolic Process Lipid Metabolic Process Lipoprotein Metabolic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cholesterol Transport Regulation Of Lipid Transport Protein-lipid Complex Assembly Lipid Homeostasis Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Clearance Phospholipid Transport Triglyceride Metabolic Process Neutral Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Cellular Lipid Metabolic Process Phospholipid Efflux Low-density Lipoprotein Particle Remodeling Cellular Biogenic Amine Metabolic Process Transport Amine Metabolic Process Lipopolysaccharide Transport Endocytosis Regulation Of Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Negative Regulation Of Lipid Catabolic Process Locomotion Regulation Of Phosphatidylcholine Catabolic Process Response To Lipid Chemical Homeostasis High-density Lipoprotein Particle Clearance Cell Motility Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Biosynthetic Process
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Intersection) ?