SMN1 and ADAMTS10

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMN1	ADAMTS10
Gene Name		survival of motor neuron 1, telomeric	ADAM metallopeptidase with thrombospondin type 1 motif, 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Microfibril Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Molecular_function Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process	Proteolysis Biological_process
Pathways		snRNP Assembly Metabolism of non-coding RNA	Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS			Height ( 20881960 18391951)
Protein-Protein Interactions		136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	7 interactors: ANXA7 CDKN1A HMGCL LAMTOR3 PCYT2 SMN1 TK1
Entrez ID		6606	81794
HPRD ID		02646	07470
Ensembl ID		ENSG00000172062	ENSG00000142303
Uniprot IDs		B4DP61 Q16637	M0QZE4 Q59FE5 Q6ZN14 Q9H324
PDB IDs		1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process	Response To Organic Substance Response To Extracellular Stimulus Fetal Process Involved In Parturition Protein Tetramerization Skeletal Muscle Cell Proliferation Digestive Tract Development Digestive System Development Liver Development Response To Glucocorticoid Response To Corticosteroid Response To Toxic Substance Leucine Catabolic Process Intestinal Epithelial Cell Maturation Response To Lipid Response To Organic Cyclic Compound Response To Cortisol Thymidine Metabolic Process Cellular Response To UV-B Deoxyribonucleoside Monophosphate Biosynthetic Process Ketone Body Biosynthetic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Leucine Metabolic Process Cellular Ketone Body Metabolic Process Stress-induced Premature Senescence Response To Metal Ion Phosphatidylethanolamine Biosynthetic Process Cellular Water Homeostasis Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development Anatomical Structure Development Parturition Regulation Of Protein Import Into Nucleus, Translocation Branched-chain Amino Acid Catabolic Process Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Positive Regulation Of TOR Signaling Response To Nutrient Levels Protein Oligomerization Response To Copper Ion Response To Inorganic Substance Response To Steroid Hormone Response To Arsenic-containing Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Gland Development
Tagcloud ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	adjuvant antitumor cdna cultured doses exert facilitate fold foundation hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt
Tagcloud (Difference) ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	adjuvant antitumor cdna cultured doses exert facilitate fold foundation hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt
Tagcloud (Intersection) ?