SMN1 and SNRPB

Number of citations of the paper that reports this interaction (PMID 9323129)
127

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SMN1	SNRPB
Gene Name		survival of motor neuron 1, telomeric	small nuclear ribonucleoprotein polypeptides B and B1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Nucleoplasm Spliceosomal Complex U7 SnRNP U1 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome SMN-Sm Protein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome Histone Pre-mRNA 3'end Processing Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Protein Binding Poly(A) RNA Binding Histone Pre-mRNA DCP Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Histone MRNA Metabolic Process RNA Splicing Gene Expression MRNA 3'-end Processing NcRNA Metabolic Process
Pathways		snRNP Assembly Metabolism of non-coding RNA	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Metabolism of non-coding RNA mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs snRNP Assembly Processing of Capped Intronless Pre-mRNA SLBP independent Processing of Histone Pre-mRNAs RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	48 interactors: ASCC2 BANP C14orf1 CALCOCO2 CD2BP2 CDKN2A CEP55 CLNS1A COIL CTDP1 DAB1 DDX20 DHX9 FNBP4 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GIGYF2 GOLGA2 IL7R KRT40 L3MBTL3 LSM11 LSM2 LSM8 PNMA1 PRMT5 PRMT7 PSMA3 RBPMS RFX6 SKIV2L SMN1 SMN2 SMNDC1 SNRPD1 SNRPD3 SNUPN SS18L1 STRAP STXBP2 STXBP3 TFIP11 TOP3B TRIM23 WBP4 WDR77
Entrez ID		6606	6628
HPRD ID		02646	01655
Ensembl ID		ENSG00000172062	ENSG00000125835
Uniprot IDs		B4DP61 Q16637	P14678 Q66K91
PDB IDs		1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI	1D3B 2Y9A 2Y9B 2Y9C 2Y9D 3CW1 3PGW
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing RNA Processing MRNA Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis Gene Expression RNA Metabolic Process Cellular Macromolecular Complex Assembly Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process NcRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Component Assembly Spliceosomal Complex Assembly Cellular Metabolic Process Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Neutrophil Degranulation Chromosome Organization Histone H4-R3 Methylation Neutrophil Activation Involved In Immune Response Peptidyl-arginine N-methylation Chromatin Organization Spliceosomal Tri-snRNP Complex Assembly Metabolic Process Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Mitotic Cell Cycle Phase Transition Transcription, DNA-templated Neutrophil Mediated Immunity Histone MRNA Metabolic Process Chromatin Modification Neutrophil Activation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Process RNA Biosynthetic Process Regulation Of T Cell Differentiation In Thymus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Pancreatic Epsilon Cell Differentiation Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration SnRNA Import Into Nucleus Spliceosomal Complex Disassembly
Tagcloud ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Difference) ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Intersection) ?