WNK1 and RBX1

Number of citations of the paper that reports this interaction (PMID 23387299)
14

Data Source:
BioGRID (enzymatic study)

		WNK1	RBX1
Gene Name		WNK lysine deficient protein kinase 1	ring-box 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Phosphatase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Phosphatase Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Neuron Development Regulation Of Cellular Process	DNA Repair Protein Monoubiquitination Notch Signaling Pathway Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Ion channel transport Stimuli-sensing channels	Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by ERBB4 Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection APC truncation mutants have impaired AXIN binding APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer Cytokine Signaling in Immune system Nuclear signaling by ERBB4 NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome degradation of DVL Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Crohn's disease ( 22936669)
Protein-Protein Interactions		37 interactors: ADRB2 AKT1 ARAF ATP8 ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 NEDD4L PFKP PRKAR1A PRKAR1B PVR RANBP9 RBX1 SLC9A1 SUMO1 SYT2 TNRC6A TSC22D1 UBC UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	58 interactors: APP BRCA1 CAND1 CCND1 CCNE1 CDC34 COPS6 CSNK1E CTNNB1 CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 DDB1 FBXO18 FBXW8 FRZB GLMN GPS1 HAX1 HIST1H1C MAP3K7 MAPK8IP2 MKNK2 MYB NFKBIA OS9 PLK1 PML PRAME RHOBTB3 RNF126 RPS6KB1 SAMHD1 SERTAD1 SKP1 SMAD3 TAB1 TP73 TRIM27 TRIM74 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2M UBE2R2 VHL VPRBP VRK2 WNK1 ZAK
Entrez ID		65125	9978
HPRD ID		05570	06794
Ensembl ID		ENSG00000060237
Uniprot IDs		A5D8Z4 F5GWT4 H6WZW3 Q9H4A3	P62877
PDB IDs			1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Intracellular Transport Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Sodium Ion Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Cellular Response To Peptide Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Establishment Of Localization In Cell Signal Transduction Cell Communication Cellular Localization Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Cell Cycle Process Cellular Response To Stimulus Cell Cycle Regulation Of Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Response To Stress Regulation Of Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process Proteolysis Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Signal Transduction Cell Death Regulation Of Cell Cycle Phase Transition Death
Tagcloud ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von
Tagcloud (Difference) ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic tceb1 tceb2 vhl von
Tagcloud (Intersection) ?