WNK1 and FLNC

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		WNK1	FLNC
Gene Name		WNK lysine deficient protein kinase 1	filamin C, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Phosphatase Binding	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Phosphatase Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Neuron Development Regulation Of Cellular Process	Cell Junction Assembly Muscle Fiber Development
Pathways		Ion channel transport Stimuli-sensing channels	Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ADRB2 AKT1 ARAF ATP8 ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 NEDD4L PFKP PRKAR1A PRKAR1B PVR RANBP9 RBX1 SLC9A1 SUMO1 SYT2 TNRC6A TSC22D1 UBC UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		65125	2318
HPRD ID		05570	00018
Ensembl ID		ENSG00000060237	ENSG00000128591
Uniprot IDs		A5D8Z4 F5GWT4 H6WZW3 Q9H4A3	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Intracellular Transport Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Sodium Ion Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Cellular Response To Peptide Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Establishment Of Localization In Cell Signal Transduction Cell Communication Cellular Localization Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process	Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation
Tagcloud ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?