DCLRE1B and TERF2

Number of citations of the paper that reports this interaction (PMID 16730175)
44

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, imaging technique)

		DCLRE1B	TERF2
Gene Name		DNA cross-link repair 1B	telomeric repeat binding factor 2
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Centrosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Mre11 Complex
	Molecular Function	Protein Binding 5'-3' Exonuclease Activity	Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Protein Homodimerization Activity
	Biological Process	Cell Cycle Checkpoint Telomere Maintenance DNA Repair Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Nucleic Acid Phosphodiester Bond Hydrolysis	Telomere Maintenance Age-dependent Telomere Shortening In Utero Embryonic Development Telomere Maintenance Via Telomerase Cell Cycle Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome, Telomeric Region Cellular Senescence
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Crohn's disease ( 23128233)
Protein-Protein Interactions		1 interactors: TERF2	55 interactors: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BLM CCDC137 CTBP1 DCLRE1B DDX21 DDX24 DDX39A EP300 GNMT H2AFX HDGFRP2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NXNL1 OCM2 ORC3 ORC6 POT1 PPM1G PRMT1 PTMA RNF113A RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 WDR4 WRN XRCC6 ZC3H18
Entrez ID		64858	7014
HPRD ID		16785	03610
Ensembl ID		ENSG00000118655	ENSG00000132604
Uniprot IDs		Q9H816	Q15554
PDB IDs		3BUA 3ZDK	1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Age-dependent Telomere Shortening Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomere Maintenance Via Telomere Shortening Telomere Capping Protein Localization To Chromosome, Telomeric Region Replicative Cell Aging Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance RNA-dependent DNA Replication Protein Localization To Chromosome Cellular Senescence Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Cell Aging Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization DNA Replication Aging Positive Regulation Of Organelle Organization	Telomere Maintenance Chromosome Organization Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Organelle Organization DNA Replication Chromatin Organization Negative Regulation Of Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Conformation Change Telomere Capping Cell Cycle Cellular Metabolic Process DNA Recombination Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Negative Regulation Of Telomere Maintenance RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Repair Chromatin Modification Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Chromosome Organization Cellular Response To Stress Cellular Response To Ionizing Radiation Regulation Of Telomere Maintenance Response To Ionizing Radiation Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination V(D)J Recombination Recombinational Repair Regulation Of Metabolic Process Cell Cycle Process Protection From Non-homologous End Joining At Telomere Negative Regulation Of DNA Metabolic Process Homeostatic Process Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?			anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal
Tagcloud (Difference) ?			anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal
Tagcloud (Intersection) ?