DCLRE1B

Gene Name		DNA cross-link repair 1B
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Centrosome
	Molecular Function	Protein Binding 5'-3' Exonuclease Activity
	Biological Process	Cell Cycle Checkpoint Telomere Maintenance DNA Repair Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Crohn's disease ( 23128233)
Protein-protein Interactions		1 interactors: TERF2
Entrez ID		64858
HPRD ID		16785
Ensembl ID		ENSG00000118655
Uniprot IDs		Q9H816
PDB IDs		3BUA 3ZDK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Age-dependent Telomere Shortening Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomere Maintenance Via Telomere Shortening Telomere Capping Protein Localization To Chromosome, Telomeric Region Replicative Cell Aging Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance RNA-dependent DNA Replication Protein Localization To Chromosome Cellular Senescence Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Cell Aging Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization DNA Replication Aging Positive Regulation Of Organelle Organization
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