TERF2 and ASS1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2	ASS1
Gene Name		telomeric repeat binding factor 2	argininosuccinate synthase 1
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Mre11 Complex	Nucleus Cytoplasm Mitochondrial Outer Membrane Lysosome Endoplasmic Reticulum Cytosol Perikaryon Extracellular Vesicular Exosome Cell Body Fiber
	Molecular Function	Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Protein Homodimerization Activity	Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Poly(A) RNA Binding
	Biological Process	Telomere Maintenance Age-dependent Telomere Shortening In Utero Embryonic Development Telomere Maintenance Via Telomerase Cell Cycle Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome, Telomeric Region Cellular Senescence	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development Arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Aging Response To Nutrient Response To Zinc Ion Response To Mycotoxin Response To Estradiol Cellular Nitrogen Compound Metabolic Process Response To Drug Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Growth Hormone Diaphragm Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis	Urea cycle Metabolism of amino acids and derivatives
Drugs			L-Arginine L-Aspartic Acid L-Citrulline Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		55 interactors: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BLM CCDC137 CTBP1 DCLRE1B DDX21 DDX24 DDX39A EP300 GNMT H2AFX HDGFRP2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NXNL1 OCM2 ORC3 ORC6 POT1 PPM1G PRMT1 PTMA RNF113A RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 WDR4 WRN XRCC6 ZC3H18	12 interactors: AKTIP APP ARAF ASCC2 ELN JAK2 MLH1 MT2A PTPN1 TERF1 TERF2 USP4
Entrez ID		7014	445
HPRD ID		03610	04590
Ensembl ID		ENSG00000132604	ENSG00000130707
Uniprot IDs		Q15554	B4E395 P00966 Q5T6L4
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C	2NZ2
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Chromosome Organization Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Organelle Organization DNA Replication Chromatin Organization Negative Regulation Of Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Conformation Change Telomere Capping Cell Cycle Cellular Metabolic Process DNA Recombination Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Negative Regulation Of Telomere Maintenance RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Repair Chromatin Modification Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Chromosome Organization Cellular Response To Stress Cellular Response To Ionizing Radiation Regulation Of Telomere Maintenance Response To Ionizing Radiation Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination V(D)J Recombination Recombinational Repair Regulation Of Metabolic Process Cell Cycle Process Protection From Non-homologous End Joining At Telomere Negative Regulation Of DNA Metabolic Process Homeostatic Process Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase	Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Proteolysis Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Telomere Maintenance Cellular Copper Ion Homeostasis Cellular Response To Interferon-gamma RNA-dependent DNA Replication Regulation Of Interferon-gamma-mediated Signaling Pathway Copper Ion Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Regulation Of Protein Phosphorylation Telomere Maintenance Via Telomere Lengthening Regulation Of Proteasomal Protein Catabolic Process Cellular Component Assembly Response To Growth Hormone Regulation Of Binding Immune Response Negative Regulation Of Cellular Metabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA Replication Regulation Of Cellular Process Regulation Of Phosphorylation Organelle Organization Regulation Of Metabolic Process JAK-STAT Cascade Homeostatic Process Regulation Of Phosphorus Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Histone H3-Y41 Phosphorylation Meiotic Metaphase I Plate Congression Host Programmed Cell Death Induced By Symbiont Meiotic Spindle Midzone Assembly Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Cellular Localization Cell Aging
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal
Tagcloud (Intersection) ?