SHC1 and PAK1

Number of citations of the paper that reports this interaction (PMID 15688026)
11

Data Source:
HPRD (in vitro)

		SHC1	PAK1
Gene Name		SHC (Src homology 2 domain containing) transforming protein 1	p21 protein (Cdc42/Rac)-activated kinase 1
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Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix Cytosol Plasma Membrane Shc-EGFR Complex	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Ephrin Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Angiogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Ras Protein Signal Transduction Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Single Organismal Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Platelet Activation Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of DNA Replication Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Pathways		Signaling by GPCR Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) SHC1 events in ERBB2 signaling IRE1alpha activates chaperones Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling SHC-mediated signalling G-protein beta:gamma signalling SHC-related events triggered by IGF1R Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling SHC1 events in ERBB4 signaling Signalling to RAS Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Signalling to ERKs IGF1R signaling cascade XBP1(S) activates chaperone genes G beta:gamma signalling through PI3Kgamma Unfolded Protein Response (UPR) Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall SHC1 events in EGFR signaling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Constitutive Signaling by EGFRvIII SHC activation	Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		134 interactors: ALK AP2A1 AP2A2 APP AXL BCL3 BCR C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FCGR2A FCGR3A FGFR1 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLSCR1 PPAP2B PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RET SH2B2 SHCBP1 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR VAV1 VAV3 ZAP70	83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83
Entrez ID		6464	5058
HPRD ID		02780	03995
Ensembl ID		ENSG00000160691	ENSG00000149269
Uniprot IDs		P29353	B3KNX7 Q13153
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C	1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Response To Organic Substance Signaling Peptidyl-tyrosine Phosphorylation Cell Communication Cellular Response To Organic Substance Regulation Of Signal Transduction Cellular Response To Stimulus Immune System Process Regulation Of Signaling Intracellular Signal Transduction Response To Stimulus Regulation Of Phosphorylation Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Protein Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Locomotion Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Innate Immune Response Positive Regulation Of Protein Metabolic Process Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Positive Regulation Of MAPK Cascade Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response
Tagcloud ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Difference) ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Intersection) ?