PAK1 and OXSR1

Number of citations of the paper that reports this interaction (PMID 14707132)
22

Data Source:
HPRD (two hybrid, in vitro)

		PAK1	OXSR1
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 1	oxidative stress responsive 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition	Protein Phosphorylation Response To Oxidative Stress Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity
Pathways		Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	10 interactors: APP BMPR1B PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1
Entrez ID		5058	9943
HPRD ID		03995	06809
Ensembl ID		ENSG00000149269	ENSG00000172939
Uniprot IDs		B3KNX7 Q13153	O95747
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC	2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response	Response To Osmotic Stress Chloride Transmembrane Transport Chloride Transport Anatomical Structure Development Hyperosmotic Response Potassium Ion Transport Developmental Process Anatomical Structure Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Inorganic Anion Transport Signal Transduction By Phosphorylation Developmental Growth System Development Peptidyl-threonine Phosphorylation Neuromuscular Junction Development Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Guidance BMP Signaling Pathway Anion Transmembrane Transport Positive Regulation Of Cell Volume Rubidium Ion Transport Cellular Hypotonic Salinity Response Cell Morphogenesis Response To Abiotic Stimulus Regulation Of Cartilage Development Neuron Differentiation Response To Stress Epithelial Cell Migration Epithelium Migration Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Ovarian Cumulus Expansion Locomotion Axonogenesis Protein Phosphorylation Axon Development Transepithelial Ammonium Transport Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Neuron Differentiation Dendrite Development Wound Healing
Tagcloud ?		advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Difference) ?		advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Intersection) ?