SHC1 and PIK3C2B

Number of citations of the paper that reports this interaction (PMID 11533253)
17

Data Source:
BioGRID (pull down)

		SHC1	PIK3C2B
Gene Name		SHC (Src homology 2 domain containing) transforming protein 1	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix Cytosol Plasma Membrane Shc-EGFR Complex	Nucleus Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Endocytic Vesicle
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Ephrin Receptor Binding	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Angiogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Ras Protein Signal Transduction Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Single Organismal Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Platelet Activation Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of DNA Replication Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Biological_process Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling
Pathways		Signaling by GPCR Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) SHC1 events in ERBB2 signaling IRE1alpha activates chaperones Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling SHC-mediated signalling G-protein beta:gamma signalling SHC-related events triggered by IGF1R Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling SHC1 events in ERBB4 signaling Signalling to RAS Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Signalling to ERKs IGF1R signaling cascade XBP1(S) activates chaperone genes G beta:gamma signalling through PI3Kgamma Unfolded Protein Response (UPR) Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall SHC1 events in EGFR signaling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Constitutive Signaling by EGFRvIII SHC activation	Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Breast cancer ( 23535733) Prostate cancer ( 23535732)
Protein-Protein Interactions		134 interactors: ALK AP2A1 AP2A2 APP AXL BCL3 BCR C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FCGR2A FCGR3A FGFR1 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLSCR1 PPAP2B PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RET SH2B2 SHCBP1 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR VAV1 VAV3 ZAP70	9 interactors: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 YWHAQ
Entrez ID		6464	5287
HPRD ID		02780	04160
Ensembl ID		ENSG00000160691	ENSG00000133056
Uniprot IDs		P29353	A2RUF7 F5GWN5 O00750
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Response To Organic Substance Signaling Peptidyl-tyrosine Phosphorylation Cell Communication Cellular Response To Organic Substance Regulation Of Signal Transduction Cellular Response To Stimulus Immune System Process Regulation Of Signaling Intracellular Signal Transduction Response To Stimulus Regulation Of Phosphorylation Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Protein Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Locomotion Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Innate Immune Response Positive Regulation Of Protein Metabolic Process Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Positive Regulation Of MAPK Cascade Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Chemotaxis Regulation Of MAPK Cascade Locomotion Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Phosphorylation System Development Regulation Of Immune Response Axon Guidance Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Multicellular Organismal Development Cell Surface Receptor Signaling Pathway
Tagcloud ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Difference) ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated	adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend
Tagcloud (Intersection) ?