PARK2 and PRKACA

Number of citations of the paper that reports this interaction (PMID 15557340)
22

Data Source:
BioGRID (enzymatic study)

		PARK2	PRKACA
Gene Name		parkin RBR E3 ubiquitin protein ligase	protein kinase, cAMP-dependent, catalytic, alpha
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Aggresome SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm LUBAC Complex Lewy Body Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Mitochondrion Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Motile Cilium AMP-activated Protein Kinase Complex Neuromuscular Junction Calcium Channel Complex Extracellular Vesicular Exosome Sperm Midpiece Ciliary Base
	Molecular Function	G-protein Coupled Receptor Binding Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity SH3 Domain Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding	CAMP-dependent Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Protein Polyubiquitination Mitochondrial Fission Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Startle Response Transcription, DNA-templated Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Regulation Of Autophagy Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Regulation Of Dopamine Secretion Protein Ubiquitination Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination Norepinephrine Metabolic Process Dopamine Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Protein K27-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Zinc Ion Homeostasis Negative Regulation Of Cell Death Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mesoderm Formation Neural Tube Closure Regulation Of Heart Rate Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Organelle Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Protein Binding Small Molecule Metabolic Process Innate Immune Response Regulation Of Osteoblast Differentiation Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Sperm Capacitation Regulation Of Insulin Secretion Regulation Of Synaptic Transmission Cytosolic Calcium Ion Homeostasis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Processing Positive Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Epinephrine Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Tight Junction Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer Metabolism of carbohydrates PKA activation Interleukin-3, 5 and GM-CSF signaling Mitotic G2-G2/M phases Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance G2/M Transition VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Loss of Nlp from mitotic centrosomes Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Cytokine Signaling in Immune system Assembly of the primary cilium Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome Centrosome maturation GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Aging ( 22773346) Disc degeneration (lumbar) ( 22993228) Metabolite levels ( 19043545) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		77 interactors: AIMP2 ARR3 ARRB2 ATXN3 BAG5 CASK CASP1 CASP8 CDK5 CHPF CRX CSNK1A1 CUL1 DLG1 DLX2 DNM1L DYT10 EPS15 FAM46C FBP1 FBXO7 FBXW7 GPR37 GRIN2B HEXDC IKBKG MEOX1 MEOX2 MFN1 NDUFA4L2 PAFAH1B2 PDCD2 PICK1 PRKACA PSMA1 PSMA7 PSMC5 PSMD4 RAC1 RAD1 RAD23A RANBP2 RBCK1 REL RGS2 RGS3 SEPT4 SEPT5 SIM2 SNCA SNCAIP STUB1 SYT11 TCF4 TOMM40 TOMM70A TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2J1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2V1 UCHL1 YWHAH ZNF746	181 interactors: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 ADRBK1 AKAP13 AKAP14 AKAP8L AKIP1 ANXA7 APC APOBEC3G ASIC1 ASIC3 ATF1 ATP2B1 AURKA BAD BCL2 BRAF CACNA1C CACNB2 CACNG2 CAD CALD1 CAMKK2 CCDC88A CCND1 CDK16 CETN1 CFTR CIITA CLDN3 CLTC CREB1 CREM CSK CUL5 CYP3A4 DMTN DNAJC5 DSP EEF2K EGFR ESR1 ETV1 FOS FXYD1 GABRB3 GABRR1 GAD1 GAD2 GFAP GJA5 GJB1 GMFB GNA13 GNMT GP1BB GRIA1 GRIA4 GSK3A GSK3B GUSB GYS1 HAND1 HAND2 HDAC1 HDAC8 HMGCR HMGN1 HMGN2 HNRNPD HSPD1 IFNAR1 IQGAP1 IRF2 ITCH ITGA2B ITGA4 ITPKA ITPKB ITPR1 ITPR2 KCNH2 KCNJ12 KCNQ1 KLF1 LCK LCP1 LIPE LRP1 MAP2 MAP3K3 MAPT MBP MC4R MEF2D MEP1B MGMT MIP NDRG1 NFKB1 NIN NOLC1 NOS1 NOXA1 NR3C1 NUP85 PARK2 PDC PDE3B PDE4B PDE4D PDPK1 PFKFB1 PFKFB2 PHKA1 PHOX2A PKIA PLIN1 PLN POU2F1 PPP1R10 PPP1R17 PPP1R1B PPP1R8 PPP1R9B PRKAR1A PSEN1 PTBP1 PTPN12 PTPN13 PTPN7 PTPRR RAF1 RANBP9 RAP1A RAP1B RAP1GAP RASGRF1 RASGRP3 RELA RGS10 RGS13 RGS14 RHOA RRAD RSBN1 RYR1 RYR2 SI SIK1 SIK3 SLC2A2 SLC4A4 SLC9A3R2 SNAP25 SNAPIN SPTBN1 SRC STK11 STMN1 STMN2 SYN1 SYN2 TBXA2R TCF3 TH THOP1 TNP1 TNP2 TPH1 TRIP10 UHRF1 VASP VIM VTN WT1
Entrez ID		5071	5566
HPRD ID		03967	03382
Ensembl ID		ENSG00000185345	ENSG00000072062
Uniprot IDs		O60260 Q5VVX4	P17612
PDB IDs		1IYF 2JMO 4BM9 4I1F 4I1H	2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Death Death Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Signaling Cell Communication Anatomical Structure Development System Development Multicellular Organismal Development Developmental Process Response To Organonitrogen Compound Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Cell Differentiation Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Process Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cellular Localization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Response To Organic Cyclic Compound Energy Reserve Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Cellular Response To Growth Factor Stimulus Cell Development Regulation Of Phosphorus Metabolic Process Response To Abiotic Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Response To Metal Ion Positive Regulation Of Catalytic Activity Cellular Process Regulation Of Phosphorylation Organ Development Neurogenesis ERBB Signaling Pathway Response To Purine-containing Compound Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Body Fluid Levels Cell-cell Signaling Synaptic Transmission Response To Stress Response To Drug
Tagcloud ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor	abrogated advance amplified bad bcl conferred discovered doi emergence frame her2 inactivated june lapatinib onc oncogene online permitting phosphoinositide pim1 publication reading rescue rescued restored sensitized trastuzumab uncover xl
Tagcloud (Difference) ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado parkin parkinsonism pn polg1 premutation rakeb tremor	abrogated advance amplified bad bcl conferred discovered doi emergence frame her2 inactivated june lapatinib onc oncogene online permitting phosphoinositide pim1 publication reading rescue rescued restored sensitized trastuzumab uncover xl
Tagcloud (Intersection) ?