PRKACA and HDAC8

Number of citations of the paper that reports this interaction (PMID 12082111)
45

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		PRKACA	HDAC8
Gene Name		protein kinase, cAMP-dependent, catalytic, alpha	histone deacetylase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Motile Cilium AMP-activated Protein Kinase Complex Neuromuscular Junction Calcium Channel Complex Extracellular Vesicular Exosome Sperm Midpiece Ciliary Base	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	CAMP-dependent Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Regulatory Subunit Binding	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mesoderm Formation Neural Tube Closure Regulation Of Heart Rate Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Organelle Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Protein Binding Small Molecule Metabolic Process Innate Immune Response Regulation Of Osteoblast Differentiation Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway Sperm Capacitation Regulation Of Insulin Secretion Regulation Of Synaptic Transmission Cytosolic Calcium Ion Homeostasis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Processing Positive Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Epinephrine Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Tight Junction Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Sister Chromatid Cohesion Chromatin Modification Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Localization To Chromatin
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer Metabolism of carbohydrates PKA activation Interleukin-3, 5 and GM-CSF signaling Mitotic G2-G2/M phases Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance G2/M Transition VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Loss of Nlp from mitotic centrosomes Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Cytokine Signaling in Immune system Assembly of the primary cilium Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome Centrosome maturation GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs			Vorinostat 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4\'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4\'-HYDROXYAMIDE 7-AMINO-4-METHYL-CHROMEN-2-ONE
Diseases
GWAS
Protein-Protein Interactions		181 interactors: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 ADRBK1 AKAP13 AKAP14 AKAP8L AKIP1 ANXA7 APC APOBEC3G ASIC1 ASIC3 ATF1 ATP2B1 AURKA BAD BCL2 BRAF CACNA1C CACNB2 CACNG2 CAD CALD1 CAMKK2 CCDC88A CCND1 CDK16 CETN1 CFTR CIITA CLDN3 CLTC CREB1 CREM CSK CUL5 CYP3A4 DMTN DNAJC5 DSP EEF2K EGFR ESR1 ETV1 FOS FXYD1 GABRB3 GABRR1 GAD1 GAD2 GFAP GJA5 GJB1 GMFB GNA13 GNMT GP1BB GRIA1 GRIA4 GSK3A GSK3B GUSB GYS1 HAND1 HAND2 HDAC1 HDAC8 HMGCR HMGN1 HMGN2 HNRNPD HSPD1 IFNAR1 IQGAP1 IRF2 ITCH ITGA2B ITGA4 ITPKA ITPKB ITPR1 ITPR2 KCNH2 KCNJ12 KCNQ1 KLF1 LCK LCP1 LIPE LRP1 MAP2 MAP3K3 MAPT MBP MC4R MEF2D MEP1B MGMT MIP NDRG1 NFKB1 NIN NOLC1 NOS1 NOXA1 NR3C1 NUP85 PARK2 PDC PDE3B PDE4B PDE4D PDPK1 PFKFB1 PFKFB2 PHKA1 PHOX2A PKIA PLIN1 PLN POU2F1 PPP1R10 PPP1R17 PPP1R1B PPP1R8 PPP1R9B PRKAR1A PSEN1 PTBP1 PTPN12 PTPN13 PTPN7 PTPRR RAF1 RANBP9 RAP1A RAP1B RAP1GAP RASGRF1 RASGRP3 RELA RGS10 RGS13 RGS14 RHOA RRAD RSBN1 RYR1 RYR2 SI SIK1 SIK3 SLC2A2 SLC4A4 SLC9A3R2 SNAP25 SNAPIN SPTBN1 SRC STK11 STMN1 STMN2 SYN1 SYN2 TBXA2R TCF3 TH THOP1 TNP1 TNP2 TPH1 TRIP10 UHRF1 VASP VIM VTN WT1	9 interactors: ESRRA HIST1H3A HIST1H4A HIST3H3 HIST4H4 MDC1 PRKACA RTN1 RUNX1T1
Entrez ID		5566	55869
HPRD ID		03382	02227
Ensembl ID		ENSG00000072062	ENSG00000147099
Uniprot IDs		P17612	Q9BY41
PDB IDs		2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9	1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Anatomical Structure Development System Development Multicellular Organismal Development Developmental Process Response To Organonitrogen Compound Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Cell Differentiation Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Process Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cellular Localization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Response To Organic Cyclic Compound Energy Reserve Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Cellular Response To Growth Factor Stimulus Cell Development Regulation Of Phosphorus Metabolic Process Response To Abiotic Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Response To Metal Ion Positive Regulation Of Catalytic Activity Cellular Process Regulation Of Phosphorylation Organ Development Neurogenesis ERBB Signaling Pathway Response To Purine-containing Compound Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Body Fluid Levels Cell-cell Signaling Synaptic Transmission Response To Stress Response To Drug	DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Nucleosome Assembly Chromatin Assembly Chromosome Organization Nucleosome Organization DNA Metabolic Process Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Megakaryocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging CENP-A Containing Nucleosome Assembly Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Chromatin Organization Protein Demethylation Mitotic Cell Cycle DNA Conformation Change Centromere Complex Assembly Nucleobase-containing Compound Metabolic Process Demethylation ATP-dependent Chromatin Remodeling Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Positive Regulation Of Dense Core Granule Biogenesis Methylation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		abrogated advance amplified bad bcl conferred discovered doi emergence frame her2 inactivated june lapatinib onc oncogene online permitting phosphoinositide pim1 publication reading rescue rescued restored sensitized trastuzumab uncover xl	activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein
Tagcloud (Difference) ?		abrogated advance amplified bad bcl conferred discovered doi emergence frame her2 inactivated june lapatinib onc oncogene online permitting phosphoinositide pim1 publication reading rescue rescued restored sensitized trastuzumab uncover xl	activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein
Tagcloud (Intersection) ?