Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
PRKACA and PFKFB1
Number of citations of the paper that reports this interaction (PMID
15896703
)
5
Data Source:
BioGRID
(enzymatic study)
PRKACA
PFKFB1
Gene Name
protein kinase, cAMP-dependent, catalytic, alpha
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Mitochondrion
Centrosome
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Membrane
Motile Cilium
AMP-activated Protein Kinase Complex
Neuromuscular Junction
Calcium Channel Complex
Extracellular Vesicular Exosome
Sperm Midpiece
Ciliary Base
Cytosol
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
Molecular Function
CAMP-dependent Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Regulatory Subunit Binding
6-phosphofructo-2-kinase Activity
Fructose-2,6-bisphosphate 2-phosphatase Activity
Protein Binding
ATP Binding
Kinase Binding
Identical Protein Binding
Fructose-6-phosphate Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Mesoderm Formation
Neural Tube Closure
Regulation Of Heart Rate
Renal Water Homeostasis
Carbohydrate Metabolic Process
Glucose Metabolic Process
Gluconeogenesis
Energy Reserve Metabolic Process
Protein Phosphorylation
Water Transport
Organelle Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Blood Coagulation
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Triglyceride Catabolic Process
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Calcium-mediated Signaling Using Intracellular Calcium Source
Regulation Of Protein Binding
Small Molecule Metabolic Process
Innate Immune Response
Regulation Of Osteoblast Differentiation
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Neurotrophin TRK Receptor Signaling Pathway
Sperm Capacitation
Regulation Of Insulin Secretion
Regulation Of Synaptic Transmission
Cytosolic Calcium Ion Homeostasis
Transmembrane Transport
Regulation Of Cardiac Muscle Contraction
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Processing
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Glucose Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Glucagon Stimulus
Cellular Response To Epinephrine Stimulus
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Regulation Of Tight Junction Assembly
Carbohydrate Metabolic Process
Fructose Metabolic Process
Fructose 2,6-bisphosphate Metabolic Process
Glucose Metabolic Process
Gluconeogenesis
Glycolytic Process
Energy Reserve Metabolic Process
Pathogenesis
Dephosphorylation
Organ Regeneration
Response To Insulin
Positive Regulation Of Glucokinase Activity
Response To Glucagon
Intracellular Signal Transduction
Response To Starvation
Small Molecule Metabolic Process
Carbohydrate Phosphorylation
Response To Glucocorticoid
Response To CAMP
Pathways
Signaling by GPCR
Ca-dependent events
CaM pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Metabolism of lipids and lipoproteins
Integration of energy metabolism
Hedgehog 'off' state
Phospholipase C-mediated cascade
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Regulation of PLK1 Activity at G2/M Transition
PLCG1 events in ERBB2 signaling
Gluconeogenesis
Glucose metabolism
DAP12 signaling
Rap1 signalling
Myoclonic epilepsy of Lafora
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
Glycogen storage diseases
PKA-mediated phosphorylation of key metabolic factors
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Recruitment of mitotic centrosome proteins and complexes
Glucagon signaling in metabolic regulation
Signaling by PDGF
Calmodulin induced events
DAP12 interactions
PKA-mediated phosphorylation of CREB
Opioid Signalling
PKA activation
Factors involved in megakaryocyte development and platelet production
Aquaporin-mediated transport
CREB phosphorylation through the activation of Adenylate Cyclase
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
PKA-mediated phosphorylation of CREB
Signaling by EGFR
Signaling by Interleukins
Signaling by VEGF
Downstream signal transduction
Calmodulin induced events
Signaling by EGFR in Cancer
Metabolism of carbohydrates
PKA activation
Interleukin-3, 5 and GM-CSF signaling
Mitotic G2-G2/M phases
Transmission across Chemical Synapses
Adaptive Immune System
Organelle biogenesis and maintenance
G2/M Transition
VEGFA-VEGFR2 Pathway
DAG and IP3 signaling
CaM pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Loss of Nlp from mitotic centrosomes
Downstream signaling of activated FGFR
DARPP-32 events
Post NMDA receptor activation events
Innate Immune System
PKA activation in glucagon signalling
Signalling by NGF
PLC beta mediated events
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
Cytokine Signaling in Immune system
Assembly of the primary cilium
Signaling by Ligand-Responsive EGFR Variants in Cancer
Lipid digestion, mobilization, and transport
NGF signalling via TRKA from the plasma membrane
G-protein mediated events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Signaling by FGFR
Loss of proteins required for interphase microtubule organization from the centrosome
PLC-gamma1 signalling
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
Centrosome maturation
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
PP2A-mediated dephosphorylation of key metabolic factors
Gluconeogenesis
Glucose metabolism
Integration of energy metabolism
Myoclonic epilepsy of Lafora
Glycogen storage diseases
PKA-mediated phosphorylation of key metabolic factors
Glycolysis
Metabolism of carbohydrates
Drugs
D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate
3-Phosphoglycerol
Phosphothiophosphoric Acid-Adenylate Ester
Guanosine-5\'-Triphosphate
Fructose-6-Phosphate
Diseases
GWAS
Protein-Protein Interactions
181 interactors:
AANAT
ABCA1
ACLY
ADCY5
ADD1
ADD2
ADRBK1
AKAP13
AKAP14
AKAP8L
AKIP1
ANXA7
APC
APOBEC3G
ASIC1
ASIC3
ATF1
ATP2B1
AURKA
BAD
BCL2
BRAF
CACNA1C
CACNB2
CACNG2
CAD
CALD1
CAMKK2
CCDC88A
CCND1
CDK16
CETN1
CFTR
CIITA
CLDN3
CLTC
CREB1
CREM
CSK
CUL5
CYP3A4
DMTN
DNAJC5
DSP
EEF2K
EGFR
ESR1
ETV1
FOS
FXYD1
GABRB3
GABRR1
GAD1
GAD2
GFAP
GJA5
GJB1
GMFB
GNA13
GNMT
GP1BB
GRIA1
GRIA4
GSK3A
GSK3B
GUSB
GYS1
HAND1
HAND2
HDAC1
HDAC8
HMGCR
HMGN1
HMGN2
HNRNPD
HSPD1
IFNAR1
IQGAP1
IRF2
ITCH
ITGA2B
ITGA4
ITPKA
ITPKB
ITPR1
ITPR2
KCNH2
KCNJ12
KCNQ1
KLF1
LCK
LCP1
LIPE
LRP1
MAP2
MAP3K3
MAPT
MBP
MC4R
MEF2D
MEP1B
MGMT
MIP
NDRG1
NFKB1
NIN
NOLC1
NOS1
NOXA1
NR3C1
NUP85
PARK2
PDC
PDE3B
PDE4B
PDE4D
PDPK1
PFKFB1
PFKFB2
PHKA1
PHOX2A
PKIA
PLIN1
PLN
POU2F1
PPP1R10
PPP1R17
PPP1R1B
PPP1R8
PPP1R9B
PRKAR1A
PSEN1
PTBP1
PTPN12
PTPN13
PTPN7
PTPRR
RAF1
RANBP9
RAP1A
RAP1B
RAP1GAP
RASGRF1
RASGRP3
RELA
RGS10
RGS13
RGS14
RHOA
RRAD
RSBN1
RYR1
RYR2
SI
SIK1
SIK3
SLC2A2
SLC4A4
SLC9A3R2
SNAP25
SNAPIN
SPTBN1
SRC
STK11
STMN1
STMN2
SYN1
SYN2
TBXA2R
TCF3
TH
THOP1
TNP1
TNP2
TPH1
TRIP10
UHRF1
VASP
VIM
VTN
WT1
5 interactors:
AKT1
APP
MAPK3
PRKACA
PRKCA
Entrez ID
5566
5207
HPRD ID
03382
02411
Ensembl ID
ENSG00000072062
ENSG00000158571
Uniprot IDs
P17612
B4DUN5
I1Z9G4
P16118
PDB IDs
2GU8
3AGL
3AGM
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
4AE6
4AE9
1K6M
Enriched GO Terms of Interacting Partners
?
Signaling
Cell Communication
Anatomical Structure Development
System Development
Multicellular Organismal Development
Developmental Process
Response To Organonitrogen Compound
Response To Stimulus
Response To Organic Substance
Cellular Response To Stimulus
Cell Differentiation
Cellular Response To Organic Substance
Cellular Response To Organonitrogen Compound
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Regulation Of Cellular Process
Signal Transduction
Neurotrophin Signaling Pathway
Regulation Of Cellular Localization
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Catalytic Activity
Response To Organic Cyclic Compound
Energy Reserve Metabolic Process
Cellular Response To Organic Cyclic Compound
Regulation Of Signaling
Cellular Response To Growth Factor Stimulus
Cell Development
Regulation Of Phosphorus Metabolic Process
Response To Abiotic Stimulus
Response To Growth Factor
Positive Regulation Of Cellular Metabolic Process
Response To Metal Ion
Positive Regulation Of Catalytic Activity
Cellular Process
Regulation Of Phosphorylation
Organ Development
Neurogenesis
ERBB Signaling Pathway
Response To Purine-containing Compound
Regulation Of Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Generation Of Neurons
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Localization
Regulation Of Body Fluid Levels
Cell-cell Signaling
Synaptic Transmission
Response To Stress
Response To Drug
Platelet Activation
Regulation Of Cellular Amino Acid Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Regulation Of Cellular Ketone Metabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Body Fluid Levels
Epidermal Growth Factor Receptor Signaling Pathway
Wound Healing
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Cell Activation
Response To Fibroblast Growth Factor
Response To Wounding
Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Positive Regulation Of Dense Core Granule Biogenesis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Kinase Activity
Innate Immune Response
Regulation Of Blood Vessel Endothelial Cell Migration
Histone H3-T6 Phosphorylation
Positive Regulation Of Cell Cycle
Apoptotic Process
Positive Regulation Of Endothelial Cell Migration
Programmed Cell Death
Positive Regulation Of Endothelial Cell Proliferation
Cell Death
Death
Regulation Of Protein Phosphorylation
Regulation Of Glucose Import
Response To Light Stimulus
Response To Abiotic Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Epithelial Cell Migration
Response To Interleukin-1
Regulation Of Endothelial Cell Proliferation
Immune Response
Regulation Of Phosphorylation
Protein Phosphorylation
Defense Response
Response To Radiation
Regulation Of Glucose Transport
Peptidyl-serine Autophosphorylation
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Endothelial Cell Migration
Tagcloud
?
abrogated
advance
amplified
bad
bcl
conferred
discovered
doi
emergence
frame
her2
inactivated
june
lapatinib
onc
oncogene
online
permitting
phosphoinositide
pim1
publication
reading
rescue
rescued
restored
sensitized
trastuzumab
uncover
xl
Tagcloud (Difference)
?
abrogated
advance
amplified
bad
bcl
conferred
discovered
doi
emergence
frame
her2
inactivated
june
lapatinib
onc
oncogene
online
permitting
phosphoinositide
pim1
publication
reading
rescue
rescued
restored
sensitized
trastuzumab
uncover
xl
Tagcloud (Intersection)
?