P4HB and ERO1L

Number of citations of the paper that reports this interaction (PMID 11707400)
61

Data Source:
HPRD (in vivo)

		P4HB	ERO1L
Gene Name		prolyl 4-hydroxylase, beta polypeptide	ERO1-like (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion Procollagen-proline 4-dioxygenase Complex Melanosome Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Disulfide Isomerase Activity Endopeptidase Activity Procollagen-proline 4-dioxygenase Activity Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor
	Biological Process	Response To Reactive Oxygen Species Protein Folding Proteolysis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Extracellular Matrix Organization Response To Endoplasmic Reticulum Stress Lipoprotein Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Response To Reactive Oxygen Species Protein Folding Cellular Protein Modification Process Response To Temperature Stimulus 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Cellular Protein Metabolic Process Cell Redox Homeostasis Brown Fat Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Release Of Sequestered Calcium Ion Into Cytosol Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		Lipoprotein metabolism Hedgehog ligand biogenesis Metabolism of lipids and lipoproteins Collagen formation Chylomicron-mediated lipid transport Processing-defective Hh variants abrogate ligand secretion Detoxification of Reactive Oxygen Species Lipid digestion, mobilization, and transport Signaling by Hedgehog Collagen biosynthesis and modifying enzymes	Peptide hormone metabolism Detoxification of Reactive Oxygen Species Insulin processing
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		17 interactors: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1L ERO1LB FEZ1 HNRNPD P4HA2 P4HA3 PRNP PTN TG UBQLN1 YWHAG	6 interactors: APPBP2 ERP44 P4HB PDIA3 PDILT PELI2
Entrez ID		5034	30001
HPRD ID		07181	13278
Ensembl ID		ENSG00000185624
Uniprot IDs		B3KTQ9 B4DUA5 F5H8J2 P07237	Q96HE7
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1	3AHQ 3AHR
Enriched GO Terms of Interacting Partners?		4-hydroxyproline Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Protein Maturation By Protein Folding Cellular Modified Amino Acid Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Peptidyl-proline Hydroxylation Protein Hydroxylation System Development Response To Endoplasmic Reticulum Stress Developmental Process Protein Trimerization Protein Maturation Endochondral Ossification Multicellular Organismal Development Anatomical Structure Development Skin Morphogenesis Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Cellular Response To Fluoride Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Alpha-amino Acid Metabolic Process Ossification Cellular Response To Organic Substance Biomineral Tissue Development Locomotion Response To Fluoride Tooth Eruption Cellular Response To Stimulus Endochondral Bone Morphogenesis Regulation Of Cellular Protein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Stimulus Axon Guidance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Amino Acid Response To Oxidative Stress Protein Oligomerization Cell Redox Homeostasis Bone Morphogenesis	Cell Redox Homeostasis Protein Folding Response To Endoplasmic Reticulum Stress Cellular Homeostasis Homeostatic Process Cellular Protein Metabolic Process
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?