P4HB and COL10A1

Number of citations of the paper that reports this interaction (PMID 10436013)
42

Data Source:
HPRD (in vivo)

		P4HB	COL10A1
Gene Name		prolyl 4-hydroxylase, beta polypeptide	collagen, type X, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion Procollagen-proline 4-dioxygenase Complex Melanosome Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Endoplasmic Reticulum Lumen Cell Cortex
	Molecular Function	Protein Disulfide Isomerase Activity Endopeptidase Activity Procollagen-proline 4-dioxygenase Activity Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Metal Ion Binding
	Biological Process	Response To Reactive Oxygen Species Protein Folding Proteolysis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Extracellular Matrix Organization Response To Endoplasmic Reticulum Stress Lipoprotein Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Skeletal System Development Endochondral Ossification Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cartilage Development
Pathways		Lipoprotein metabolism Hedgehog ligand biogenesis Metabolism of lipids and lipoproteins Collagen formation Chylomicron-mediated lipid transport Processing-defective Hh variants abrogate ligand secretion Detoxification of Reactive Oxygen Species Lipid digestion, mobilization, and transport Signaling by Hedgehog Collagen biosynthesis and modifying enzymes	Collagen formation Collagen degradation Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23455636 21665990)
Protein-Protein Interactions		17 interactors: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1L ERO1LB FEZ1 HNRNPD P4HA2 P4HA3 PRNP PTN TG UBQLN1 YWHAG	4 interactors: ANXA5 BANP P4HB UBQLN1
Entrez ID		5034	1300
HPRD ID		07181	00357
Ensembl ID		ENSG00000185624	ENSG00000123500
Uniprot IDs		B3KTQ9 B4DUA5 F5H8J2 P07237	Q03692
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1	1GR3
Enriched GO Terms of Interacting Partners?		4-hydroxyproline Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Protein Maturation By Protein Folding Cellular Modified Amino Acid Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Peptidyl-proline Hydroxylation Protein Hydroxylation System Development Response To Endoplasmic Reticulum Stress Developmental Process Protein Trimerization Protein Maturation Endochondral Ossification Multicellular Organismal Development Anatomical Structure Development Skin Morphogenesis Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Cellular Response To Fluoride Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Alpha-amino Acid Metabolic Process Ossification Cellular Response To Organic Substance Biomineral Tissue Development Locomotion Response To Fluoride Tooth Eruption Cellular Response To Stimulus Endochondral Bone Morphogenesis Regulation Of Cellular Protein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Stimulus Axon Guidance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Amino Acid Response To Oxidative Stress Protein Oligomerization Cell Redox Homeostasis Bone Morphogenesis	Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cell Death Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline 4-hydroxyproline Metabolic Process Peptidyl-proline Hydroxylation Protein Hydroxylation
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	agc aggrecan biocompatibility biomechanical chondrocyte coating compressive cooh engineering fn functionalization functionalized hydrogels laden modulus nanocomposite nanocomposites nanotubes peg pellet reinforcement scaffolds swnt swnts tensile tolerate ultimate
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	agc aggrecan biocompatibility biomechanical chondrocyte coating compressive cooh engineering fn functionalization functionalized hydrogels laden modulus nanocomposite nanocomposites nanotubes peg pellet reinforcement scaffolds swnt swnts tensile tolerate ultimate
Tagcloud (Intersection) ?