MEN1 and VIM

Number of citations of the paper that reports this interaction (PMID 12169273)
12

Data Source:
HPRD (in vivo, in vitro)

		MEN1	VIM
Gene Name		multiple endocrine neoplasia I	vimentin
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Cleavage Furrow Histone Methyltransferase Complex Protein Complex	Cytoplasm Peroxisome Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein Binding, Bridging Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding R-SMAD Binding	Glycoprotein Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein C-terminus Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Leukocyte Homeostasis Negative Regulation Of Protein Phosphorylation Osteoblast Fate Commitment Osteoblast Development DNA Repair Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Cell Proliferation Response To UV Response To Gamma Radiation Gene Expression Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Methylation Positive Regulation Of Protein Binding Regulation Of Activin Receptor Signaling Pathway Histone Lysine Methylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Embryonic Skeletal System Morphogenesis Positive Regulation Of Cell Division Negative Regulation Of Telomerase Activity Palate Development Maternal Process Involved In Female Pregnancy	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Muscle Filament Sliding Intermediate Filament Organization Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer formation of the beta-catenin:TCF transactivating complex Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer	Apoptotic cleavage of cellular proteins Striated Muscle Contraction Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		32 interactors: ASH2L CTNNB1 DBF4 ESR1 FANCD2 FOXN3 GFAP HDAC1 HDAC2 HIST1H3A HIST3H3 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF4 TP53 VIM	140 interactors: ABLIM1 AKT1 ALS2CR11 ANKRD35 ANXA7 APIP APLP1 APP ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CDH5 CDK1 CDKN1A CHD3 COPS6 CRCT1 CREB1 CRMP1 CWF19L2 DCTN1 DEFB1 DGCR14 DIS3L2 DNM1L DPPA4 DSP DYNLL1 EIF3I FABP4 FAM107A FAM118B FUBP1 GADD45A GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HTRA2 ING5 ITGB4 IVNS1ABP KARS KAT7 KIAA0408 KIAA1377 KIF15 KRT20 LOR LRIF1 MAFG MAN2A2 MEN1 MICAL1 MRPL44 NEFL NFATC2 NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PRKACA PRPH PSMA1 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SDCCAG3 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRT6 SLC25A6 SLC27A6 SMAD3 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCHP TNFRSF14 TNNT1 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1D1 YWHAE YWHAZ ZHX1 ZNF384
Entrez ID		4221	7431
HPRD ID		00564	01899
Ensembl ID		ENSG00000133895	ENSG00000026025
Uniprot IDs		O00255 Q9GZQ5	P08670
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80	1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Chromosome Organization RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Response To Stress Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cell Differentiation Cellular Response To Stimulus Anatomical Structure Development Response To Stimulus Chromatin Organization Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Organelle Organization Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Differentiation	Programmed Cell Death Apoptotic Process Cell Death Death Execution Phase Of Apoptosis Regulation Of Cell Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Proteolysis Regulation Of Cellular Localization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Organelle Organization Cell Cycle Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Gene Expression Immune System Process Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Positive Regulation Of Signal Transduction Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Programmed Cell Death Cellular Process Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Viral Process Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Difference) ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z
Tagcloud (Intersection) ?