VIM and KARS

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		VIM	KARS
Gene Name		vimentin	lysyl-tRNA synthetase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Glycoprotein Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein C-terminus Binding Identical Protein Binding Scaffold Protein Binding	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Muscle Filament Sliding Intermediate Filament Organization Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process
Pathways		Apoptotic cleavage of cellular proteins Striated Muscle Contraction Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs			L-Lysine
Diseases
GWAS
Protein-Protein Interactions		140 interactors: ABLIM1 AKT1 ALS2CR11 ANKRD35 ANXA7 APIP APLP1 APP ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CDH5 CDK1 CDKN1A CHD3 COPS6 CRCT1 CREB1 CRMP1 CWF19L2 DCTN1 DEFB1 DGCR14 DIS3L2 DNM1L DPPA4 DSP DYNLL1 EIF3I FABP4 FAM107A FAM118B FUBP1 GADD45A GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HTRA2 ING5 ITGB4 IVNS1ABP KARS KAT7 KIAA0408 KIAA1377 KIF15 KRT20 LOR LRIF1 MAFG MAN2A2 MEN1 MICAL1 MRPL44 NEFL NFATC2 NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PRKACA PRPH PSMA1 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SDCCAG3 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRT6 SLC25A6 SLC27A6 SMAD3 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCHP TNFRSF14 TNNT1 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1D1 YWHAE YWHAZ ZHX1 ZNF384	15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM
Entrez ID		7431	3735
HPRD ID		01899	03249
Ensembl ID		ENSG00000026025	ENSG00000065427
Uniprot IDs		P08670	Q15046
PDB IDs		1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1	3BJU 4DPG
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Apoptotic Process Cell Death Death Execution Phase Of Apoptosis Regulation Of Cell Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Proteolysis Regulation Of Cellular Localization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Organelle Organization Cell Cycle Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Gene Expression Immune System Process Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Positive Regulation Of Signal Transduction Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Programmed Cell Death Cellular Process Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Viral Process Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging
Tagcloud ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Difference) ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Intersection) ?