MEN1 and ASH2L

Number of citations of the paper that reports this interaction (PMID 14992727)
152

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MEN1	ASH2L
Gene Name		multiple endocrine neoplasia I	ash2 (absent, small, or homeotic)-like (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Cleavage Furrow Histone Methyltransferase Complex Protein Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein Binding, Bridging Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding R-SMAD Binding	DNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Leukocyte Homeostasis Negative Regulation Of Protein Phosphorylation Osteoblast Fate Commitment Osteoblast Development DNA Repair Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Negative Regulation Of Cell Proliferation Response To UV Response To Gamma Radiation Gene Expression Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Methylation Positive Regulation Of Protein Binding Regulation Of Activin Receptor Signaling Pathway Histone Lysine Methylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Embryonic Skeletal System Morphogenesis Positive Regulation Of Cell Division Negative Regulation Of Telomerase Activity Palate Development Maternal Process Involved In Female Pregnancy	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer formation of the beta-catenin:TCF transactivating complex Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer	Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS		Urate levels ( 21768215)	Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		32 interactors: ASH2L CTNNB1 DBF4 ESR1 FANCD2 FOXN3 GFAP HDAC1 HDAC2 HIST1H3A HIST3H3 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF4 TP53 VIM	22 interactors: BARD1 BRCA1 CHD8 CTNNB1 DPY30 EP300 HCFC2 HIST1H3A HIST3H3 KMT2A KMT2D MEN1 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1
Entrez ID		4221	9070
HPRD ID		00564	05309
Ensembl ID		ENSG00000133895	ENSG00000129691
Uniprot IDs		O00255 Q9GZQ5	B4DPT1 F5H8F7 Q9UBL3
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80	3RSN 3S32 3TOJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Chromosome Organization RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Response To Stress Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cell Differentiation Cellular Response To Stimulus Anatomical Structure Development Response To Stimulus Chromatin Organization Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Organelle Organization Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Differentiation	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Histone Modification Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Biosynthetic Process Chromosome Organization Positive Regulation Of Histone Methylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Histone Methylation Regulation Of Histone Modification Positive Regulation Of Transcription, DNA-templated Regulation Of Histone Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Positive Regulation Of Gene Expression Protein Methylation Negative Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Nucleobase-containing Compound Metabolic Process Chromatin Modification Regulation Of Chromosome Organization Histone Modification Heterocycle Metabolic Process
Tagcloud ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Difference) ?		11p15 11q13 adenomatous adrenal adrenocortical allelic altogether atypia beckwith clarification constitution demand endocrine enlargement excess exhibiting handling heterozygosity hyperplastic immunostaining insufficiently losses mitogenic overrepresented phospholipase plc proinsulin radiologic wiedemann	acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wdr5 wrad
Tagcloud (Intersection) ?