SMAD5 and ZEB2

Number of citations of the paper that reports this interaction (PMID 10400677)
88

Data Source:
HPRD (two hybrid)

		SMAD5	ZEB2
Gene Name		SMAD family member 5	zinc finger E-box binding homeobox 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	DNA Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Somitogenesis Neural Tube Closure Transcription, DNA-templated Nervous System Development Hippocampus Development Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Melanocyte Migration Regulation Of Melanosome Organization
Pathways		Signaling by BMP
Drugs
Diseases
GWAS			Epilepsy (generalized) ( 22949513) Obesity-related traits ( 23251661) Renal cell carcinoma ( 23184150)
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	11 interactors: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I
Entrez ID		4090	9839
HPRD ID		04381	05780
Ensembl ID		ENSG00000113658	ENSG00000169554
Uniprot IDs		Q68DB7 Q99717	O60315
PDB IDs			2DA7
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Pattern Specification Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Regulation Of Transcription, DNA-templated Urogenital System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Regulation Of RNA Metabolic Process Cellular Response To DsRNA RNA Metabolic Process Cellular Protein Modification Process Posttranscriptional Gene Silencing Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Fate Commitment Mullerian Duct Regression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Viral Process Skeletal System Development Gene Silencing By RNA Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Binding Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 inducing mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1
Tagcloud (Intersection) ?		inducing