SMAD5 and UBA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMAD5	UBA1
Gene Name		SMAD family member 5	ubiquitin-like modifier activating enzyme 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Heterochromatin Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Modification-dependent Protein Catabolic Process
Pathways		Signaling by BMP	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	39 interactors: BUB3 CDC34 CDK1 CREB3L1 CREB3L2 ECHS1 GAN GRB2 HGS HSPH1 MGMT PIAS3 SEMA3F SMAD5 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2K UBE2L3 UBE2R2 UBE2S UBE2T UBE2W UBTD2
Entrez ID		4090	7317
HPRD ID		04381	02440
Ensembl ID		ENSG00000113658	ENSG00000130985
Uniprot IDs		Q68DB7 Q99717	P22314
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteolysis Catabolic Process Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Protein Monoubiquitination Cellular Response To Stress Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Response To Organic Substance Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 3 Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Spindle Assembly Checkpoint
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	aspect bax box consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Intersection) ?		caspases