SMAD5 and BCAT1

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD5	BCAT1
Gene Name		SMAD family member 5	branched chain amino-acid transaminase 1, cytosolic
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Branched-chain-amino-acid Transaminase Activity Identical Protein Binding L-leucine Transaminase Activity L-valine Transaminase Activity L-isoleucine Transaminase Activity
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	G1/S Transition Of Mitotic Cell Cycle Cell Proliferation Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways		Signaling by BMP	Branched-chain amino acid catabolism Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Glutamic Acid L-Leucine L-Valine L-Isoleucine N\'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
Diseases
GWAS			Response to statin therapy ( 20339536) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	3 interactors: KDM1A PRMT6 SMAD5
Entrez ID		4090	586
HPRD ID		04381	00216
Ensembl ID		ENSG00000113658	ENSG00000060982
Uniprot IDs		Q68DB7 Q99717	P54687
PDB IDs			2ABJ 2COG 2COI 2COJ
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Regulation Of Primitive Erythrocyte Differentiation Histone H3-R2 Methylation Myeloid Cell Differentiation Mullerian Duct Regression Histone Modification Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Transcription, DNA-templated RNA Biosynthetic Process Osteoblast Fate Commitment Positive Regulation Of Megakaryocyte Differentiation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H4-R3 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Chromatin Modification Anatomical Structure Regression Granulocyte Differentiation Hemopoiesis Peptidyl-arginine N-methylation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation RNA Metabolic Process Immune System Development Cellular Protein Modification Process Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Chromatin Organization Peptidyl-arginine Methylation Regulation Of Histone H3-K4 Methylation Cellular Response To BMP Stimulus Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hormone Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Histone Lysine Demethylation Regulation Of Hormone Metabolic Process Histone Demethylation Regulation Of Erythrocyte Differentiation
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	atf4 axonal believe branched cage catabolism crush ddit3 differentially dynamism eyes ganglion glaucoma highlighting ifng log2 onc optic orchestrating pathomechanisms presumably retinas revealing rgc rgcs sequenced serves silico transaminase
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	atf4 axonal believe branched cage catabolism crush ddit3 differentially dynamism eyes ganglion glaucoma highlighting ifng log2 onc optic orchestrating pathomechanisms presumably retinas revealing rgc rgcs sequenced serves silico transaminase
Tagcloud (Intersection) ?