SIMC1 and TUBA4A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SIMC1	TUBA4A
Gene Name		SUMO-interacting motifs containing 1	tubulin, alpha 4a
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome
	Molecular Function	SUMO Polymer Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization
Pathways			Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs			Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CSNK2B DNAJB11 PLK1 TUBA4A YWHAG YWHAZ	49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		375484	7277
HPRD ID		13486	01851
Ensembl ID		ENSG00000170085	ENSG00000127824
Uniprot IDs		B4DRM7 Q8NDZ2	A8MUB1 P68366
PDB IDs
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Mitochondrion Organization Mitotic Cell Cycle Process Cellular Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of APC-Cdc20 Complex Activity Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Polar Body Extrusion After Meiotic Divisions Golgi Reassembly Platelet Activation Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Negative Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Kinase Activity Histamine Secretion By Mast Cell Positive Regulation Of Intracellular Transport Cell Cycle Process Response To Organic Substance Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Establishment Of Golgi Localization Regulation Of Binding Response To Stimulus Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway Golgi Inheritance Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Difference) ?			34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Intersection) ?