SIMC1 and DNAJB11

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SIMC1	DNAJB11
Gene Name		SUMO-interacting motifs containing 1	DnaJ (Hsp40) homolog, subfamily B, member 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane
	Molecular Function	SUMO Polymer Binding	Protein Binding Unfolded Protein Binding
	Biological Process		Protein Folding Activation Of Signaling Protein Activity Involved In Unfolded Protein Response MRNA Modification Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process
Pathways			IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CSNK2B DNAJB11 PLK1 TUBA4A YWHAG YWHAZ	23 interactors: ANKZF1 APOBEC1 BAG6 CEP70 COL6A1 CRMP1 DDAH2 DNAJC13 DRAP1 EIF3D EZH2 FAF1 GRB2 HSPA1A PAXIP1 PTN SIMC1 SNX5 SPRED1 SUMO4 UBQLN4 UBR1 ZZZ3
Entrez ID		375484	51726
HPRD ID		13486	07485
Ensembl ID		ENSG00000170085	ENSG00000090520
Uniprot IDs		B4DRM7 Q8NDZ2	Q9UBS4
PDB IDs
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Regulation Of Phosphorylation Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Mitochondrion Organization Mitotic Cell Cycle Process Cellular Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of APC-Cdc20 Complex Activity Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Polar Body Extrusion After Meiotic Divisions Golgi Reassembly Platelet Activation Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Negative Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Kinase Activity Histamine Secretion By Mast Cell Positive Regulation Of Intracellular Transport Cell Cycle Process Response To Organic Substance Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Establishment Of Golgi Localization Regulation Of Binding Response To Stimulus Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Activin Receptor Signaling Pathway Golgi Inheritance Positive Regulation Of Cellular Protein Metabolic Process	Peptidyl-lysine Modification Catabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signal Transduction Response To Ionizing Radiation Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Regulation Of Metabolic Process Positive Regulation Of Histone H3-K36 Methylation Cellular Response To Amino Acid Stimulus Cellular Heat Acclimation Regulation Of Early Endosome To Recycling Endosome Transport Cytidine To Uridine Editing Cellular Response To Leucine Formation Of Cytoplasmic Translation Initiation Complex Ossification Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Methylation-dependent Chromatin Silencing DNA Modification Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone Lysine Methylation Protein Stabilization Regulation Of Protein Complex Assembly Chromatin Organization Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Regulation Of Methylation-dependent Chromatin Silencing Locomotion Regulation Of Protein Catabolic Process Axon Guidance Signal Transduction By P53 Class Mediator Response To Amino Acid
Tagcloud ?			aggregation attenuates chaperoning clients destabilized erdj3 evade extracellular hsp40 indirectly influences links metazoan misfolded overwhelmed preemptively prion prone proteostasis proteotoxic proteotoxicity remodeling revealing secrete secretion space substoichiometrically unfolded upr
Tagcloud (Difference) ?			aggregation attenuates chaperoning clients destabilized erdj3 evade extracellular hsp40 indirectly influences links metazoan misfolded overwhelmed preemptively prion prone proteostasis proteotoxic proteotoxicity remodeling revealing secrete secretion space substoichiometrically unfolded upr
Tagcloud (Intersection) ?