ACACA and CHGB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACACA	CHGB
Gene Name		acetyl-CoA carboxylase alpha	chromogranin B (secretogranin 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Extracellular Region Secretory Granule
	Molecular Function	Acetyl-CoA Carboxylase Activity Biotin Carboxylase Activity Protein Binding ATP Binding Metal Ion Binding	Hormone Activity Protein Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Carnitine Shuttle Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Multicellular Organismal Protein Metabolic Process Small Molecule Metabolic Process Protein Homotetramerization Lipid Homeostasis Malonyl-CoA Biosynthetic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Import of palmitoyl-CoA into the mitochondrial matrix Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism
Drugs		Biotin
Diseases
GWAS		Ovarian cancer ( 23535730)
Protein-Protein Interactions		9 interactors: ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 PRKAA1 PRKAA2 PRKAB1 PRKAG1	31 interactors: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 MARK3 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SGK223 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		31	1114
HPRD ID		01938	07512
Ensembl ID		ENSG00000132142	ENSG00000089199
Uniprot IDs		B2ZZ90 Q13085 Q7Z5W8	P05060
PDB IDs		2YL2 3COJ 4ASI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Fatty Acid Biosynthetic Process Regulation Of Cell Cycle Cell Cycle Process Cell Cycle Fatty Acid Metabolic Process Regulation Of Glycolytic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Protein Phosphorylation Wnt Signaling Pathway Response To Insulin Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Chromosome Organization Response To Organonitrogen Compound Biosynthetic Process Regulation Of Gene Expression Response To Hormone Cellular Lipid Metabolic Process Phosphorylation Cellular Protein Modification Process Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process Carboxylic Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Peptide Hormone Fatty Acid Homeostasis Protein Heterooligomerization Positive Regulation Of Metabolic Process Regulation Of Lipid Biosynthetic Process Signaling Response To Peptide Cell Communication Organic Acid Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Lipid Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Glucose Starvation Regulation Of Chromosome Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Checkpoint	Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Developmental Growth Cellular Metabolic Process Cellular Component Assembly Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Cell Differentiation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Synaptic Transmission Response To Metal Ion Response To Lipid Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cell Development Generation Of Neurons Response To Growth Factor Phosphate-containing Compound Metabolic Process Response To Organic Cyclic Compound Protein Homotetramerization Platelet Activation Positive Regulation Of Metabolic Process Response To Stress Metabolic Process Neurogenesis Response To Organic Substance Positive Regulation Of Lamellipodium Assembly Cellular Process Apoptotic Process Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Defense Response Hemostasis DNA-templated Transcription, Initiation Negative Regulation Of Developmental Growth Response To Wounding Long Term Synaptic Depression Programmed Cell Death Regulation Of Neurogenesis Nucleotide-excision Repair Positive Regulation Of Lamellipodium Organization Negative Regulation Of Growth Cell Death Death Cell Development Regulation Of Protein Import Into Nucleus, Translocation Developmental Process Regulation Of Cell Morphogenesis Response To Inorganic Substance
Tagcloud ?		aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg	adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von
Tagcloud (Difference) ?		aldehyde aldh antifungal biosynthesis capability carboxylase catalyzed coa committed csc impeded intermediates lipogenesis mammosphere mcf novo oleic overexpress participates polyketide renewal silenced siphoning soraphen supraphysiological unrecognized warburg	adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von
Tagcloud (Intersection) ?