GTF2I and AP2B1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		GTF2I	AP2B1
Gene Name		general transcription factor IIi	adaptor-related protein complex 2, beta 1 subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Cell Projection Neuronal Cell Body	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Binding	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Transition Between Slow And Fast Fiber Negative Regulation Of Angiogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways			Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		35 interactors: AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 DPY30 GCC1 HDAC3 JAK2 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 TAB2 TRAF6 USF1 YY1 ZBTB17 ZMYM3	44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1
Entrez ID		2969	163
HPRD ID		03399	03015
Ensembl ID		ENSG00000077809	ENSG00000006125
Uniprot IDs		A8K9W7 P78347 Q499G6 Q86U51	K7EJT8 P63010 Q96EL6
PDB IDs		2D9B 2DN4 2ED2 2EJE	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Gene Expression Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Hormone Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cell Communication Multicellular Organismal Development Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process	Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process
Tagcloud ?		74146970t ab aggressive assessment bap1 carcinomas cdkn2a classification complement cyld delta facilitate indolent isoforms missense mutation next notably pbrm1 rarely recurrent sequencing stimulate subtype subtypes tets thymic thymomas tp53	17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?		74146970t ab aggressive assessment bap1 carcinomas cdkn2a classification complement cyld delta facilitate indolent isoforms missense mutation next notably pbrm1 rarely recurrent sequencing stimulate subtype subtypes tets thymic thymomas tp53	17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?