GNAO1 and SCN8A

Number of citations of the paper that reports this interaction (PMID 10066808)
2

Data Source:
HPRD (in vitro, in vivo)

		GNAO1	SCN8A
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	sodium channel, voltage gated, type VIII alpha subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Z Disc Dendrite Node Of Ranvier Neuronal Cell Body Axon Initial Segment
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Voltage-gated Sodium Channel Activity ATP Binding
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Muscle Organ Development Sensory Perception Of Sound Adult Walking Behavior Response To Toxic Substance Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuromuscular Process Membrane Depolarization During Action Potential
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	3 interactors: FGF13 GNAO1 MAPK14
Entrez ID		2775	6334
HPRD ID		00757	09006
Ensembl ID		ENSG00000087258	ENSG00000196876
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	Q9UQD0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	P38MAPK Cascade MAPK Cascade Positive Regulation Of Catalytic Activity Establishment Of Neuroblast Polarity Signal Transduction By Phosphorylation Aging Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Collateral Sprouting Forebrain Development Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Kinase Activity Stress-induced Premature Senescence Positive Regulation Of Transferase Activity Behavior Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cartilage Condensation Cell Differentiation Positive Regulation Of Metabolic Process Brain Development Skeletal Muscle Tissue Regeneration Regulation Of Kinase Activity Microtubule Polymerization MRNA Stabilization Head Development Somatic Stem Cell Division Response To Organonitrogen Compound Cellular Senescence Positive Regulation Of Phosphorylation Positive Regulation Of Myotube Differentiation Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Microtubule Depolymerization Lipopolysaccharide-mediated Signaling Pathway Response To Morphine Central Nervous System Development Negative Regulation Of Calcium Ion Transport Microtubule Polymerization Or Depolymerization
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect segregating seizures suited syngap1 synj1 translating unrevealing wes
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	asah1 atypical broadening canada care4rare causal definitive descriptions encephalopathy epilepsy exome families folr1 forge grin2a kcnq2 nation projects rare recognizable retrospect segregating seizures suited syngap1 synj1 translating unrevealing wes
Tagcloud (Intersection) ?