GNAO1 and FFAR2

Number of citations of the paper that reports this interaction (PMID 12711604)
105

Data Source:
HPRD (in vivo)

		GNAO1	FFAR2
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	free fatty acid receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Plasma Membrane Integral Component Of Plasma Membrane Cell Projection
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Leukocyte Chemotaxis Involved In Inflammatory Response Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G-protein Coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Chemokine Production Glucose Homeostasis Fat Cell Differentiation Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Free fatty acid receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	4 interactors: CYB5R2 GNAO1 GNAQ IGF1R
Entrez ID		2775	2867
HPRD ID		00757	04824
Ensembl ID		ENSG00000087258	ENSG00000126262
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	C6KYL4 O15552
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Dopamine Receptor Signaling Pathway Brain Development Head Development Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Inactivation Of MAPKK Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuron Development Central Nervous System Development Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Generation Of Neurons Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Neurogenesis Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Negative Regulation Of Phosphorylation Positive Regulation Of Hormone Biosynthetic Process Cell Development Forebrain Development Regulation Of Melanocyte Differentiation Male Sex Determination Maternal Behavior Response To Vitamin E Insulin-like Growth Factor Receptor Signaling Pathway Nervous System Development Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Catalytic Activity Regulation Of Developmental Pigmentation Phosphatidylinositol 3-kinase Signaling Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Neuron Maturation Positive Regulation Of GTPase Activity Regulation Of Hormone Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Muscle Cell Apoptotic Process Forebrain Neuron Development Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of Cytokinesis Regulation Of Kinase Activity Prostate Gland Epithelium Morphogenesis
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	acetate alter autonomous believed coupling elevation encoded expect ffa2 ffa3 ffar3 gi glucose hyperglycemia inability indeed insufficient islets maintain obese pancreatic profound proper respond secretion stimulate summary tolerance worldwide
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	acetate alter autonomous believed coupling elevation encoded expect ffa2 ffa3 ffar3 gi glucose hyperglycemia inability indeed insufficient islets maintain obese pancreatic profound proper respond secretion stimulate summary tolerance worldwide
Tagcloud (Intersection) ?