GNAO1 and PDE6H

Number of citations of the paper that reports this interaction (PMID 15215290)
17

Data Source:
HPRD (two hybrid)

		GNAO1	PDE6H
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	phosphodiesterase 6H, cGMP-specific, cone, gamma
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Enzyme Inhibitor Activity CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Activation Of MAPK Activity Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Stimulus
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	4 interactors: AGTR1 APP COTL1 GNAO1
Entrez ID		2775	5149
HPRD ID		00757	03116
Ensembl ID		ENSG00000087258	ENSG00000139053
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	Q13956
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Phospholipase C-activating Angiotensin-activated Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hydrolase Activity Collateral Sprouting In Absence Of Injury Positive Regulation Of NAD(P)H Oxidase Activity Locomotory Behavior Renin-angiotensin Regulation Of Aldosterone Production Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Phospholipase A2 Activity Regulation Of Blood Vessel Size By Renin-angiotensin Cellular Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Regulation Of NAD(P)H Oxidase Activity Angiotensin-activated Signaling Pathway Neuron Remodeling Positive Regulation Of Cholesterol Esterification Cellular Metal Ion Homeostasis Response To External Stimulus Regulation Of Cholesterol Esterification Response To Oxidative Stress Regulation Of Phospholipase A2 Activity Low-density Lipoprotein Particle Remodeling Cellular Cation Homeostasis Forebrain Development Regulation Of Blood Volume By Renin-angiotensin Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Chemical Homeostasis Cellular Copper Ion Homeostasis Ion Homeostasis Regulation Of Renal Sodium Excretion Behavior Chemotaxis Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Regulation Of Growth Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Excretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Plasma Lipoprotein Particle Remodeling Defense Response To Fungus Positive Regulation Of Steroid Metabolic Process Cellular Homeostasis Neuron Maturation
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?