KLHL20 and CRMP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KLHL20	CRMP1
Gene Name		kelch-like family member 20	collapsin response mediator protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		15 interactors: ACTA1 ARHGEF12 C14orf1 CORO7 CRMP1 CUL3 ECT2 EPAS1 GBP2 KIAA1377 LRIF1 LUC7L2 PIN1 PRMT6 SUV39H1	78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24
Entrez ID		27252	1400
HPRD ID		13918	03913
Ensembl ID		ENSG00000076321	ENSG00000072832
Uniprot IDs		Q9Y2M5	B3KT07 E9PD68 Q14194 Q96I11
PDB IDs			4B3Z
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokinesis Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytokinesis Anatomical Structure Morphogenesis Cell Morphogenesis Positive Regulation Of Rho GTPase Activity Regulation Of Cell Division Regulation Of Ras Protein Signal Transduction Regulation Of Rho GTPase Activity Cellular Component Assembly Actin Filament Organization Regulation Of Small GTPase Mediated Signal Transduction Cell Cycle Apoptotic Signaling Pathway Regulation Of Chromosome Segregation Histone H3-R2 Methylation Skeletal Muscle Fiber Adaptation Organelle Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Trophectodermal Cellular Morphogenesis Cellular Response To Oxygen Levels Positive Regulation Of Ras GTPase Activity Actomyosin Structure Organization Cell Differentiation Regulation Of Mitotic Nuclear Division Histone Methylation Positive Regulation Of Cell Division Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Cell Cycle Process Anatomical Structure Formation Involved In Morphogenesis Response To Abiotic Stimulus Cell Development Regulation Of Ras GTPase Activity Skeletal Muscle Thin Filament Assembly Histone H3-K9 Dimethylation Myoblast Fate Commitment Cytoskeleton Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Pyrimidine Nucleobase Catabolic Process Skeletal Myofibril Assembly Protein Methylation Actin Cytoskeleton Organization Skeletal Muscle Adaptation Adhesion Of Symbiont To Host	Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process
Tagcloud ?		angiopoietin bioinformatic blocking candidates canonical corneae corneal correlating correspondingly dystrophic dystrophy ect2 grew incomplete kelch kleip limbus lymphatics microarrays microrna mir neovascular neovascularization options pharmaceutical player proangiogenic vegf vision	aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		angiopoietin bioinformatic blocking candidates canonical corneae corneal correlating correspondingly dystrophic dystrophy ect2 grew incomplete kelch kleip limbus lymphatics microarrays microrna mir neovascular neovascularization options pharmaceutical player proangiogenic vegf vision	aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?