CRMP1 and PPP1R8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CRMP1	PPP1R8
Gene Name		collapsin response mediator protein 1	protein phosphatase 1, regulatory subunit 8
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	DNA Binding RNA Binding Endonuclease Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Type 1 Regulator Activity Ribonuclease E Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance	Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing RNA Catabolic Process Cell Proliferation RNA Splicing Negative Regulation Of Catalytic Activity RNA Phosphodiester Bond Hydrolysis
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24	24 interactors: APP APPBP2 C14orf1 CDC5L CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED FBXO25 GBP2 HDAC2 HMGA1 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 SETDB1 SF3B1 STC2 WDR77
Entrez ID		1400	5511
HPRD ID		03913	04028
Ensembl ID		ENSG00000072832	ENSG00000117751
Uniprot IDs		B3KT07 E9PD68 Q14194 Q96I11	Q12972 Q6ICT4
PDB IDs		4B3Z	3V4Y
Enriched GO Terms of Interacting Partners?		Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process	Response To External Stimulus Triglyceride Catabolic Process Cellular Protein Modification Process Acylglycerol Catabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression MRNA Metabolic Process RNA Metabolic Process RNA Processing RNA Splicing Chemotaxis Developmental Process Multicellular Organismal Development System Development Axon Guidance Cellular Protein Metabolic Process Chromatin Organization Response To Abiotic Stimulus Circadian Regulation Of Gene Expression Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Neuron Projection Development Cellular Metabolic Process Triglyceride Metabolic Process Regulation Of Platelet Aggregation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Axonogenesis Anatomical Structure Development Neutral Lipid Metabolic Process Axon Development Rhythmic Process Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chromatin Modification Neuron Development Entrainment Of Circadian Clock By Photoperiod Apoptotic Process Response To Light Stimulus Photoperiodism Entrainment Of Circadian Clock Programmed Cell Death Chromosome Organization
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?