KLHL20 and EPAS1

Number of citations of the paper that reports this interaction (PMID 21888897)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KLHL20	EPAS1
Gene Name		kelch-like family member 20	endothelial PAS domain protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Transcription Factor Complex Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Transcription From RNA Polymerase II Promoter Mitochondrion Organization Signal Transduction Visual Perception Erythrocyte Differentiation Lung Development Somatic Stem Cell Maintenance Norepinephrine Metabolic Process Surfactant Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Myoblast Fate Commitment Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS			Renal cell carcinoma ( 21131975)
Protein-Protein Interactions		15 interactors: ACTA1 ARHGEF12 C14orf1 CORO7 CRMP1 CUL3 ECT2 EPAS1 GBP2 KIAA1377 LRIF1 LUC7L2 PIN1 PRMT6 SUV39H1	32 interactors: APC ARNT ARNT2 ARNTL ARNTL2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 EWSR1 F12 HSP90AA1 JUN KLHL20 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP VHL
Entrez ID		27252	2034
HPRD ID		13918	06787
Ensembl ID		ENSG00000076321	ENSG00000116016
Uniprot IDs		Q9Y2M5	B3KW07 Q99814
PDB IDs			1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokinesis Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytokinesis Anatomical Structure Morphogenesis Cell Morphogenesis Positive Regulation Of Rho GTPase Activity Regulation Of Cell Division Regulation Of Ras Protein Signal Transduction Regulation Of Rho GTPase Activity Cellular Component Assembly Actin Filament Organization Regulation Of Small GTPase Mediated Signal Transduction Cell Cycle Apoptotic Signaling Pathway Regulation Of Chromosome Segregation Histone H3-R2 Methylation Skeletal Muscle Fiber Adaptation Organelle Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Trophectodermal Cellular Morphogenesis Cellular Response To Oxygen Levels Positive Regulation Of Ras GTPase Activity Actomyosin Structure Organization Cell Differentiation Regulation Of Mitotic Nuclear Division Histone Methylation Positive Regulation Of Cell Division Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Cell Cycle Process Anatomical Structure Formation Involved In Morphogenesis Response To Abiotic Stimulus Cell Development Regulation Of Ras GTPase Activity Skeletal Muscle Thin Filament Assembly Histone H3-K9 Dimethylation Myoblast Fate Commitment Cytoskeleton Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Pyrimidine Nucleobase Catabolic Process Skeletal Myofibril Assembly Protein Methylation Actin Cytoskeleton Organization Skeletal Muscle Adaptation Adhesion Of Symbiont To Host	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Response To Stimulus Anatomical Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process System Development Developmental Process Nitrogen Compound Metabolic Process RNA Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Cellular Response To Oxygen Levels Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Leukocyte Activation Biosynthetic Process Leukocyte Differentiation Response To External Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Myeloid Leukocyte Differentiation
Tagcloud ?		angiopoietin bioinformatic blocking candidates canonical corneae corneal correlating correspondingly dystrophic dystrophy ect2 grew incomplete kelch kleip limbus lymphatics microarrays microrna mir neovascular neovascularization options pharmaceutical player proangiogenic vegf vision	2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Difference) ?		angiopoietin bioinformatic blocking candidates canonical corneae corneal correlating correspondingly dystrophic dystrophy ect2 grew incomplete kelch kleip limbus lymphatics microarrays microrna mir neovascular neovascularization options pharmaceutical player proangiogenic vegf vision	2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Intersection) ?