GDF9 and BMP15

Number of citations of the paper that reports this interaction (PMID 12446716)
23

Data Source:
HPRD (in vitro)

		GDF9	BMP15
Gene Name		growth differentiation factor 9	bone morphogenetic protein 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cell Development SMAD Protein Signal Transduction Regulation Of Progesterone Secretion	Ovarian Follicle Development Female Gamete Generation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Transcription, DNA-templated Cell Development Granulosa Cell Development SMAD Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CCDC53 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3	2 interactors: BMPR1B GDF9
Entrez ID		2661	9210
HPRD ID		03560	02216
Ensembl ID		ENSG00000164404	ENSG00000130385
Uniprot IDs		B4DXG3 O60383	O95972
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Chondrocyte Proliferation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Developmental Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process System Development Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Ossification Nitrogen Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune System Process Regulation Of Cell Death RNA Metabolic Process RNA Processing Phosphate-containing Compound Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Gene Expression Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Gene Expression Regulation Of Phosphorylation Regulation Of Cell Growth Organ Development Gastrulation Positive Regulation Of Metabolic Process	BMP Signaling Pathway Oogenesis Female Gamete Generation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Developmental Growth Ovarian Cumulus Expansion Oocyte Growth Negative Regulation Of Chondrocyte Proliferation Regulation Of Progesterone Secretion Growth Oogenesis Stage Antral Ovarian Follicle Growth Gamete Generation Developmental Process Involved In Reproduction Regulation Of Female Gonad Development Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Enzyme Linked Receptor Protein Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Reproduction Cartilage Condensation Single Organism Reproductive Process Chondrocyte Development Positive Regulation Of Signal Transduction Reproductive Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Regulation Of Apoptotic Process Oocyte Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Pathway-restricted SMAD Protein Phosphorylation Proteoglycan Biosynthetic Process SMAD Protein Signal Transduction Ovarian Follicle Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Endochondral Bone Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Chondrocyte Differentiation Developmental Cell Growth
Tagcloud ?		3h bmp bmp15 bmpr2 decapentaplegic differing granulosa incorporation involves jnk jun kb mapk morphogenetic mothers ovine p3h pathways signalling sma smad smad1 smad2 steroid stimulate synergistic synergistically thymidine utilised	124a 16c 2039a 351a 397c 538a 538g 769a 769g 788instct 852c 919a 9c accumulative allelic asian asians caucasian cgg cnki esr1 ethnicity fmr1 fshr inception inha pof premutation revman
Tagcloud (Difference) ?		3h bmp bmpr2 decapentaplegic differing granulosa incorporation involves jnk jun kb mapk morphogenetic mothers ovine p3h pathways signalling sma smad smad1 smad2 steroid stimulate synergistic synergistically thymidine utilised	124a 16c 2039a 351a 397c 538a 538g 769a 769g 788instct 852c 919a 9c accumulative allelic asian asians caucasian cgg cnki esr1 ethnicity fmr1 fshr inception inha pof premutation revman
Tagcloud (Intersection) ?		bmp15