GDF9 and PCDHA4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GDF9	PCDHA4
Gene Name		growth differentiation factor 9	protocadherin alpha 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Integral Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity	Calcium Ion Binding
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cell Development SMAD Protein Signal Transduction Regulation Of Progesterone Secretion	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CCDC53 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3	15 interactors: APLP1 C14orf1 CCDC90B EEF1A1 GAPDH GDF9 IGSF21 LRIF1 RBM48 RELN SETDB1 SGTA TLE1 TP53 UNC119
Entrez ID		2661	56144
HPRD ID		03560	07322
Ensembl ID		ENSG00000164404	ENSG00000204967
Uniprot IDs		B4DXG3 O60383	Q59H34 Q9UN74
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Chondrocyte Proliferation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Developmental Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process System Development Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Ossification Nitrogen Compound Metabolic Process Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune System Process Regulation Of Cell Death RNA Metabolic Process RNA Processing Phosphate-containing Compound Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Osteoblast Differentiation Gene Expression Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Gene Expression Regulation Of Phosphorylation Regulation Of Cell Growth Organ Development Gastrulation Positive Regulation Of Metabolic Process	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Neuron Death Regulation Of Phosphorus Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Lateral Motor Column Neuron Migration Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Macromitophagy Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth Oligodendrocyte Apoptotic Process Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Long-term Synaptic Potentiation Lateral Motor Column Neuron Migration Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Response To Norepinephrine Stimulus Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Growth Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Spinal Cord Motor Neuron Migration Regulation Of Progesterone Secretion Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Notch Signaling Pathway Regulation Of RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Peptidyl-cysteine S-nitrosylation N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Response To Growth Factor Stimulus
Tagcloud ?		3h bmp bmp15 bmpr2 decapentaplegic differing granulosa incorporation involves jnk jun kb mapk morphogenetic mothers ovine p3h pathways signalling sma smad smad1 smad2 steroid stimulate synergistic synergistically thymidine utilised
Tagcloud (Difference) ?		3h bmp bmp15 bmpr2 decapentaplegic differing granulosa incorporation involves jnk jun kb mapk morphogenetic mothers ovine p3h pathways signalling sma smad smad1 smad2 steroid stimulate synergistic synergistically thymidine utilised
Tagcloud (Intersection) ?