EEF1G and LZTS1

Number of citations of the paper that reports this interaction (PMID 11504921)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EEF1G	LZTS1
Gene Name		eukaryotic translation elongation factor 1 gamma	leucine zipper, putative tumor suppressor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasm Postsynaptic Density Apical Plasma Membrane Cell Junction Dendritic Spine Dendritic Shaft Cell Body Postsynaptic Membrane
	Molecular Function	Translation Elongation Factor Activity Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Negative Regulation Of Macroautophagy Regulation Of Dendrite Morphogenesis
Pathways		Translation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS			Circulating myeloperoxidase levels (serum) ( 23620142) Dental caries ( 23064961 23259602) Major depressive disorder (broad) ( 20038947) Preeclampsia ( 23551011)
Protein-Protein Interactions		87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24	3 interactors: CDC25C CDK1 EEF1G
Entrez ID		1937	11178
HPRD ID		11745	05945
Ensembl ID		ENSG00000254772	ENSG00000061337
Uniprot IDs		P26641 Q53YD7	Q9Y250
PDB IDs		1PBU
Enriched GO Terms of Interacting Partners?		Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity	G2/M Transition Of Mitotic Cell Cycle Pronuclear Fusion Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Mitotic Nuclear Division Regulation Of Schwann Cell Differentiation Regulation Of Mitotic Cell Cycle Cell Division Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Mitotic Cell Cycle Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Sexual Reproduction Cellular Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Positive Regulation Of Cardiac Muscle Cell Proliferation Macromolecule Biosynthetic Process G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly Regulation Of Cell Cycle Positive Regulation Of Heart Growth Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Cardiac Muscle Cell Proliferation Reproduction Cell Cycle Process DNA Metabolic Process Regulation Of Protein Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Positive Regulation Of Organ Growth Response To Amine Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Activity Centrosome Cycle Response To Cadmium Ion Regulation Of Heart Growth Toll-like Receptor TLR6:TLR2 Signaling Pathway
Tagcloud ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	acquisition allow cap1 castration cdc25c chek1 chemoresistance develops differentially docetaxel focused igr killed kinases largely microarray mitotic nsc663284 overcome parental partner plk1 prostate resistance resistant signature sirna subset targets
Tagcloud (Difference) ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	acquisition allow cap1 castration cdc25c chek1 chemoresistance develops differentially docetaxel focused igr killed kinases largely microarray mitotic nsc663284 overcome parental partner plk1 prostate resistance resistant signature sirna subset targets
Tagcloud (Intersection) ?