ECT2 and NOMO1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		ECT2	NOMO1
Gene Name		epithelial cell transforming 2	NODAL modulator 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Cellular_component Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Molecular_function Carbohydrate Binding
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Biological_process
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	12 interactors: ATF7IP BAG6 ECT2 EXOSC10 NCLN SHBG STAT1 TOM1L1 TRIM55 TRIM63 UBQLN4 UPF2
Entrez ID		1894	23420
HPRD ID		11860	11398
Ensembl ID		ENSG00000114346	ENSG00000103512
Uniprot IDs		G5E9L8 Q9H8V3	Q15155
PDB IDs		3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Cellular Macromolecule Catabolic Process Negative Regulation Of Macrophage Fusion Primary Spermatocyte Growth Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Ubiquitin-dependent Protein Catabolic Process Response To Hydrogen Peroxide Modification-dependent Protein Catabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Metanephric Mesenchymal Cell Differentiation Nuclear-transcribed MRNA Catabolic Process Cellular Protein Catabolic Process RNA Localization MRNA Catabolic Process Skeletal Muscle Atrophy Protein Catabolic Process Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Striated Muscle Atrophy Nuclear MRNA Surveillance Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Catabolic Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Muscle Atrophy Response To Reactive Oxygen Species Regulation Of Proteasomal Protein Catabolic Process Protein Insertion Into ER Membrane RNA Surveillance Skeletal Muscle Adaptation Mesenchymal Cell Differentiation Involved In Kidney Development Histone MRNA Catabolic Process Regulation Of Gene Expression, Epigenetic Dosage Compensation By Inactivation Of X Chromosome Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Intracellular MRNA Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dosage Compensation RRNA Catabolic Process Cell Differentiation Involved In Metanephros Development
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Intersection) ?