ECT2 and GGN

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ECT2	GGN
Gene Name		epithelial cell transforming 2	gametogenetin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex	Nucleolus Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity	Protein Dimerization Activity
	Biological Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway	Multicellular Organismal Development Gamete Generation Spermatogenesis Protein Localization Cell Differentiation
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2	7 interactors: BRCA1 ECT2 FANCL GGNBP1 GGNBP2 KRT40 OAZ3
Entrez ID		1894	199720
HPRD ID		11860	17036
Ensembl ID		ENSG00000114346	ENSG00000179168
Uniprot IDs		G5E9L8 Q9H8V3	Q86UU5
PDB IDs		3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition	Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Single Organism Reproductive Process Reproductive Process Spermatogenesis Male Gamete Generation Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Putrescine Transport Positive Regulation Of Histone H3-K9 Acetylation Response To Ionizing Radiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Microtubule-based Process Negative Regulation Of Polyamine Transmembrane Transport Cellular Response To Indole-3-methanol Positive Regulation Of Cell Cycle Process Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Apoptotic Signaling Pathway Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Activation Of Rac GTPase Activity Negative Regulation Of Histone Methylation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Cellular Response To Stress Polyamine Biosynthetic Process Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Cdc42 GTPase Activity Negative Regulation Of Protein Acetylation
Tagcloud ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	bcg bovis confocal domain except gfp gga immunoblot immunofluorescence localization localizes maintain missing mtb mycobacteria mycobacterial mycobacterium pathogenic pe pgrs pgrs30 polar poles repeats repetitive smegmatis tagged unique virulence
Tagcloud (Difference) ?		broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly	bcg bovis confocal domain except gfp gga immunoblot immunofluorescence localization localizes maintain missing mtb mycobacteria mycobacterial mycobacterium pathogenic pe pgrs pgrs30 polar poles repeats repetitive smegmatis tagged unique virulence
Tagcloud (Intersection) ?